E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital

Manas Talukdar, Aparajita Samaddar, Saikat Bhattacharya.

Abstract
Background: Most of the patients of Coronavirus Disease-19 (COVID-19) presented with mild symptoms and recovered, but a considerable number of cases deteriorated and succumbed to death. They often present with hemostatic abnormalities mimicking disseminated intravascular coagulation with increased risk of thrombosis rather than bleeding. Hence, early prediction of disease severity by some easily available hematological parameters might be helpful to reduce mortality in COVID-19 cases.

Aim and Objectives: The aim of the study was to determine whether values of Prothrombin Time (PT), International Normalized Ratio (INR), Activated Partial Thromboplastin Time (APTT) and D-Dimer (DD) correlate with disease severity in COVID-19 and also to find out cutoff value of these parameters to predict disease severity.

Materials and Methods: This observational cross-sectional study was done on total 400 hospitalized COVID-19 adult patients where patients were categorized into moderate and severe cases as per guideline of Government of India. Patients with pre-existing coagulation disorder or receiving anticoagulant drugs were excluded from the study. PT, INR, APTT, and DD values of these two groups were evaluated and compared statistically to determine their significance and the cut-off value to predict severity.

Results: Among the measured blood parameters means of PT (P < 0.001), INR (P < 0.001) and DD (P < 0.001) found to be significantly higher in the severe group of patients compared to moderate ones and DD value ≥1.365 mg/L indicates severe disease. APTT showed no statistically significant association with severity.

Conclusion: PT and INR can be used as severity marker in COVID-19 patients; however, DD is the most reliable marker correlating with disease severity.

Key words: Coronavirus Disease-19; D-Dimer; International Normalized Ratio


 
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How to Cite this Article
Pubmed Style

Talukdar M, Samaddar A, Bhattacharya S. Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. doi:10.5455/njppp.2022.12.07265202102082021


Web Style

Talukdar M, Samaddar A, Bhattacharya S. Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. http://www.njppp.com/?mno=103191 [Access: October 01, 2021]. doi:10.5455/njppp.2022.12.07265202102082021


AMA (American Medical Association) Style

Talukdar M, Samaddar A, Bhattacharya S. Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. doi:10.5455/njppp.2022.12.07265202102082021



Vancouver/ICMJE Style

Talukdar M, Samaddar A, Bhattacharya S. Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. doi:10.5455/njppp.2022.12.07265202102082021



Harvard Style

Talukdar, M., Samaddar, . A. & Bhattacharya, . S. (2022) Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. doi:10.5455/njppp.2022.12.07265202102082021



Turabian Style

Talukdar, Manas, Aparajita Samaddar, and Saikat Bhattacharya. 2022. Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. doi:10.5455/njppp.2022.12.07265202102082021



Chicago Style

Talukdar, Manas, Aparajita Samaddar, and Saikat Bhattacharya. "Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital." doi:10.5455/njppp.2022.12.07265202102082021



MLA (The Modern Language Association) Style

Talukdar, Manas, Aparajita Samaddar, and Saikat Bhattacharya. "Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital." doi:10.5455/njppp.2022.12.07265202102082021



APA (American Psychological Association) Style

Talukdar, M., Samaddar, . A. & Bhattacharya, . S. (2022) Coagulation profile and D-dimer level in hospitalized COVID-19 patients: A cross-sectional study in a tertiary care hospital. doi:10.5455/njppp.2022.12.07265202102082021