E-ISSN 2231-3206 | ISSN 2320-4672
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|Educational Strategies|| |
Understanding and application of clinical pharmacokinetic principles using single compartment pharmacokinetic simulation model
Ashishkumar Zala, ND Kantharia, Aashal B Shah.
To simplify the principles of pharmacokinetics single compartment model is designed with certain assumptions. Objectives of this model are to understand basic principles of pharmacokinetics, to represent graphically the typical natural log concentration versus time curve for single compartment model after (intravenous) dose and to understand how to calculate elimination half-life using graphical log-concentration versus time as well as by mathematical method.
Pharmacokinetic, Clearance, Volume of distribution, Half life ,Optical density, area under curve (AUC)
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