E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
18 / 01 / 2015

 


Biochemical role of serum fructosamine in patients with thyroid disorders

Nagraj Soni, GG Kaushik, Neha Sharma.


Abstract
Background: Fructosamine (FA) is the product of a reaction between glucose (sugar) and albumin (protein). It is used to monitor the short-term glycemic changes in patients with diabetes and may have a role in conjugation with glycated hemoglobin.

Aims & Objective: Fructosamine test is used to evaluate the average amount of glucose in blood over a period of 2–3 weeks. FA is a useful indicator to measure the peripheral metabolic function in patients with thyroid disorders. As serum thyroid function tests, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), serum FA ratios occupied our attention, their inconsistency in the subjects with subclinical hypothyroidism, overt hypothyroidism, and hyperthyroidism in relation to the euthyroid healthy control subjects was studied here.

Materials and Methods: This study was conducted on 100 patients with overt hypothyroidism, subclinical hypothyroidism, and hyperthyroidism attending the medical OPD and radioimmunoassay laboratory of the Department of Biochemistry, Jawaharlal Nehru Medical College and Hospital, Ajmer, Rajasthan, India.

Results: The mean glycated hemoglobin level was higher in study group than in controls, and it was not statistically significant. The mean serum FA level was higher in patients with overt hypothyroidism and subclinical hyperthyroidism and lower in those with hyperthyroidism than that in controls. It was found to be highly statistically significant.

Conclusion: The FA values, which are largely higher than FPG and HbA1c values, indicate a higher propensity to glycation and a decrease turnover of the proteins in the patients with overt hypothyroidism and subclinical hypothyroidism; contrary results were observed in individuals with hyperthyroidism.

Key words: Thyroid; Hypothyroid, Hyperthyroid; Fructosamine


 
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Pubmed Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 50-53. doi:10.5455/njppp.2015.5.290720141


Web Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. https://www.njppp.com/?mno=164387 [Access: March 16, 2024]. doi:10.5455/njppp.2015.5.290720141


AMA (American Medical Association) Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 50-53. doi:10.5455/njppp.2015.5.290720141



Vancouver/ICMJE Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol. (2015), [cited March 16, 2024]; 5(1): 50-53. doi:10.5455/njppp.2015.5.290720141



Harvard Style

Nagraj Soni, GG Kaushik, Neha Sharma (2015) Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol, 5 (1), 50-53. doi:10.5455/njppp.2015.5.290720141



Turabian Style

Nagraj Soni, GG Kaushik, Neha Sharma. 2015. Biochemical role of serum fructosamine in patients with thyroid disorders. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 50-53. doi:10.5455/njppp.2015.5.290720141



Chicago Style

Nagraj Soni, GG Kaushik, Neha Sharma. "Biochemical role of serum fructosamine in patients with thyroid disorders." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 50-53. doi:10.5455/njppp.2015.5.290720141



MLA (The Modern Language Association) Style

Nagraj Soni, GG Kaushik, Neha Sharma. "Biochemical role of serum fructosamine in patients with thyroid disorders." National Journal of Physiology, Pharmacy and Pharmacology 5.1 (2015), 50-53. Print. doi:10.5455/njppp.2015.5.290720141



APA (American Psychological Association) Style

Nagraj Soni, GG Kaushik, Neha Sharma (2015) Biochemical role of serum fructosamine in patients with thyroid disorders. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 50-53. doi:10.5455/njppp.2015.5.290720141