E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Biochemical role of serum fructosamine in patients with thyroid disorders

Nagraj Soni, GG Kaushik, Neha Sharma.

Abstract
Background: Fructosamine (FA) is the product of a reaction between glucose (sugar) and albumin (protein). It is used to monitor the short-term glycemic changes in patients with diabetes and may have a role in conjugation with glycated hemoglobin.

Aims & Objective: Fructosamine test is used to evaluate the average amount of glucose in blood over a period of 2–3 weeks. FA is a useful indicator to measure the peripheral metabolic function in patients with thyroid disorders. As serum thyroid function tests, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), serum FA ratios occupied our attention, their inconsistency in the subjects with subclinical hypothyroidism, overt hypothyroidism, and hyperthyroidism in relation to the euthyroid healthy control subjects was studied here.

Materials and Methods: This study was conducted on 100 patients with overt hypothyroidism, subclinical hypothyroidism, and hyperthyroidism attending the medical OPD and radioimmunoassay laboratory of the Department of Biochemistry, Jawaharlal Nehru Medical College and Hospital, Ajmer, Rajasthan, India.

Results: The mean glycated hemoglobin level was higher in study group than in controls, and it was not statistically significant. The mean serum FA level was higher in patients with overt hypothyroidism and subclinical hyperthyroidism and lower in those with hyperthyroidism than that in controls. It was found to be highly statistically significant.

Conclusion: The FA values, which are largely higher than FPG and HbA1c values, indicate a higher propensity to glycation and a decrease turnover of the proteins in the patients with overt hypothyroidism and subclinical hypothyroidism; contrary results were observed in individuals with hyperthyroidism.

Key words: Thyroid; Hypothyroid, Hyperthyroid; Fructosamine


 
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REFERENCES
1. Barker J, OÂ’Connor J, Metcalf P, Lawson M R, Johnson R N. Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus. Br Med . 1983;287:863-70. [DOI via Crossref]   
2. Burtis C, Ashwood E, Bruns, D. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 4th edn. St. Louis, MO: Elsevier Saunders, 2006.
3. Hara H, Ban Y, Taniyama M, Sato R, Kushima K, Nagakura H, et al. The significance of serum fructosamine measurement in patients with thyroid diseases. Nihon Naibunpi Gakkai Zasshi. 1990;66(10):1075-84. [DOI via Crossref]   
4. Ford HC, Lim WC, Crooke MJ. HemoglobinA1c and serum fructosamine levels in hyperthyroidism. Clin Chem Acta.1987;166:317-21. [DOI via Crossref]   
5. Jayaprasad N, Francis J. Atrial fibrillation and hyperthyroidism. Indian Pacing Electrophysiol J. 2005;5(4):305-11.
6. Kim HB, Han KH, Lee BW, Kim H, Lee MH, Chung ES, et al. HbA1c and serum fructosamine levels in hyperthyroidism. J Korean Soc Endocrinol. 1992;7:46-51.
7. Larsen PR, Terry FD (Eds.). Williams Textbook of Endocrinology, 10th edn. WB Saunders, 2002. pp. 423-48.
8. Nanda N, Bobby Z, Hamide A. Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference. Clin Exp Med. 2008;8:101-8. [DOI via Crossref]    [Pubmed]   
9. Billic-Komarica E, Beciragic A, Junuzovic D. The importance of HbA1c control in patients with subclinical hypothyroidism. Mater Sociomed. 2012;24(4):212-19. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Delpierre G, Collard F, Fortpied J, Van Schaftingen E. Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes. Biochem J. 2002;365:801-8.
11. Goldstein DE. Is glycosylated hemoglobin clinically useful. N Engl J Med.1984;310:384-5
12. Caraccio N, Ferrannini E, Monzani F. Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo controlled study. J Clin Endocrinol Metab. 2002;87(4):1533-8. [DOI via Crossref]    [Pubmed]   
13. Indla YR, Dasari S, Sunder RR, Kumar PR, Kumari RS. Clinical study of radioactive iodine uptake in different goiter cases in correlation with normal individuals. Int J Biomed Res. 2012;3(3):151-6. [DOI via Crossref]   
14. Higai K, Sano R, Satake M, Azuma Y, Matsumoto K. Glycated human serum albumin induces interleukin 8 mRNA expression through reactive oxygen species and NADPH oxidase-dependent pathway in monocyte-derived U937cells. Biol Pharm Bull. 2007;30(10):1833-7. [DOI via Crossref]    [Pubmed]   
15. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994) National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metabol. 2002;87(2):489-99. [DOI via Crossref]    [Pubmed]   
16. Arrigo T, Wasniewska M, Crisafulli G, Lombardo F, Messina M F, Rulli I, et al. Subclinical hypothyroidism: the state of the art. J Endocrinol Invest. 2008; 31(1):79-84. [DOI via Crossref]    [Pubmed]   
17. Karmisholt J, Andersen S, Laurberg P. Variation in thyroid function in subclinical hypothyroidism: importance of clinical follow-up and therapy. Eur J Endocrinol. 2011;164:317-23. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 50-53. doi:10.5455/njppp.2015.5.290720141


Web Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. http://www.njppp.com/?mno=164387 [Access: May 22, 2019]. doi:10.5455/njppp.2015.5.290720141


AMA (American Medical Association) Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 50-53. doi:10.5455/njppp.2015.5.290720141



Vancouver/ICMJE Style

Nagraj Soni, GG Kaushik, Neha Sharma. Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol. (2015), [cited May 22, 2019]; 5(1): 50-53. doi:10.5455/njppp.2015.5.290720141



Harvard Style

Nagraj Soni, GG Kaushik, Neha Sharma (2015) Biochemical role of serum fructosamine in patients with thyroid disorders. Natl J Physiol Pharm Pharmacol, 5 (1), 50-53. doi:10.5455/njppp.2015.5.290720141



Turabian Style

Nagraj Soni, GG Kaushik, Neha Sharma. 2015. Biochemical role of serum fructosamine in patients with thyroid disorders. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 50-53. doi:10.5455/njppp.2015.5.290720141



Chicago Style

Nagraj Soni, GG Kaushik, Neha Sharma. "Biochemical role of serum fructosamine in patients with thyroid disorders." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 50-53. doi:10.5455/njppp.2015.5.290720141



MLA (The Modern Language Association) Style

Nagraj Soni, GG Kaushik, Neha Sharma. "Biochemical role of serum fructosamine in patients with thyroid disorders." National Journal of Physiology, Pharmacy and Pharmacology 5.1 (2015), 50-53. Print. doi:10.5455/njppp.2015.5.290720141



APA (American Psychological Association) Style

Nagraj Soni, GG Kaushik, Neha Sharma (2015) Biochemical role of serum fructosamine in patients with thyroid disorders. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 50-53. doi:10.5455/njppp.2015.5.290720141





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