E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats

Chandrashekar K, Rajashekar Y R, Ganesan R.

Abstract
Background: Dipeptidyl peptidase-4 enzyme not only inhibits incretins but also many other substrates and has wide distribution. Inhibition of this enzyme may have many implications, one of which is to improve wound healing.

Aims and Objectives: This aim of this study is to evaluate wound healing property of linagliptin, saxagliptin, sitagliptin, and vildagliptin on excised wounds in non-diabetic Wistar albino rats.

Materials and Methods: Some commonly used gliptins, linagliptin, saxagliptin, sitagliptin, and vildagliptin were assessed for pro-wound healing property on excised wound in non-diabetic Wistar albino rats. Wound healing was assessed by measuring the scar area at 4,8,12 & 16 days and the time taken for the complete scar formation.On the 16th day, rats were sacrificed, wound tissue biopsy was taken for assessing granulation tissue and serum was subjected for tumor necrosis factor-1α, interleukin-6, inducible nitric oxide synthase, hydroxyproline and glucose estimation.

Results: Pro-healing property was not uniform among various tested gliptins, only linagliptin and sitagliptin were found to have improved wound healing potential in rat excised wound.

Conclusion: Gliptins show variable effect on wound healing.

Key words: Dipeptidyl Peptidase-4 Enzyme; Pro-wound Healing Property


 
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Pubmed Style

Chandrashekar K, Rajashekar Y R, Ganesan R. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1359-1363. doi:10.5455/njppp.2017.7.0832224082017


Web Style

Chandrashekar K, Rajashekar Y R, Ganesan R. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. https://www.njppp.com/?mno=275661 [Access: June 01, 2022]. doi:10.5455/njppp.2017.7.0832224082017


AMA (American Medical Association) Style

Chandrashekar K, Rajashekar Y R, Ganesan R. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Vancouver/ICMJE Style

Chandrashekar K, Rajashekar Y R, Ganesan R. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol. (2017), [cited June 01, 2022]; 7(12): 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Harvard Style

Chandrashekar K, Rajashekar Y R, Ganesan R (2017) Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol, 7 (12), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Turabian Style

Chandrashekar K, Rajashekar Y R, Ganesan R. 2017. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Chicago Style

Chandrashekar K, Rajashekar Y R, Ganesan R. "Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



MLA (The Modern Language Association) Style

Chandrashekar K, Rajashekar Y R, Ganesan R. "Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 7.12 (2017), 1359-1363. Print. doi:10.5455/njppp.2017.7.0832224082017



APA (American Psychological Association) Style

Chandrashekar K, Rajashekar Y R, Ganesan R (2017) Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017