E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 4
14 / 4Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research

Online Publishing Date:
17 / 11 / 2017

 


The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus)

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor.


Abstract
Background: Pramiracetam is being used, particularly by students, to increase cognitive function and enhance learning and memory. There are currently sparse data on the effect of pramiracetam, particularly in the brain. One recent study showed that there is an increased nitric oxide synthase (NOS) in systemically administered pramiracetam.

Aims and Objectives: To determine if there would be a demyelinating effect in the hippocampus that is a sign of neurological damage due to increasing nitric oxide synthase.

Materials and Methods: A total of fifteen mice were given 200 and 600 mg/kg dose of pramiracetam for qualitative histological comparison of their hippocampal myelination. After administration with food of the pramiracetam for 75 days, the mice were sacrificed and the brains were then extracted intact, and sagittal sections of the brain were made and stained with the Klüver-Barrera method. Hippocampi were analyzed using a compound microscope to observe for demyelination and neuronal degeneration.

Results: Based on histological analysis, there were no signs of demyelination in the hippocampus of the Mus musculus brain. This may indicate that pramiracetam does not cause demyelination that may be due to increased NO production.

Conclusion: Pramiracetam may be safe to take at doses of 200–600 mg/kg without any demyelinating effects in mouse.

Key words: Demyelination; Hippocampus; Mus musculus; Pramiracetam


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Adrian Cielo S Angeles
Articles by Michael B Ples
Articles by Rodel Jonathan S Vitor
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). Natl J Physiol Pharm Pharmacol. 2018; 8(3): 431-435. doi:10.5455/njppp.2017.7.0832609112017

Web Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). https://www.njppp.com/?mno=275760 [Access: March 16, 2024]. doi:10.5455/njppp.2017.7.0832609112017

AMA (American Medical Association) Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). Natl J Physiol Pharm Pharmacol. 2018; 8(3): 431-435. doi:10.5455/njppp.2017.7.0832609112017


Vancouver/ICMJE Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). Natl J Physiol Pharm Pharmacol. (2018), [cited March 16, 2024]; 8(3): 431-435. doi:10.5455/njppp.2017.7.0832609112017


Harvard Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor (2018) The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). Natl J Physiol Pharm Pharmacol, 8 (3), 431-435. doi:10.5455/njppp.2017.7.0832609112017


Turabian Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. 2018. The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). National Journal of Physiology, Pharmacy and Pharmacology, 8 (3), 431-435. doi:10.5455/njppp.2017.7.0832609112017


Chicago Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. "The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus)." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 431-435. doi:10.5455/njppp.2017.7.0832609112017


MLA (The Modern Language Association) Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor. "The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus)." National Journal of Physiology, Pharmacy and Pharmacology 8.3 (2018), 431-435. Print. doi:10.5455/njppp.2017.7.0832609112017


APA (American Psychological Association) Style

Adrian Cielo S Angeles, Michael B Ples, Rodel Jonathan S Vitor (2018) The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus). National Journal of Physiology, Pharmacy and Pharmacology, 8 (3), 431-435. doi:10.5455/njppp.2017.7.0832609112017


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

  National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Publisher

publishernjppp@gmail.com

 

Editorial query

editornjppp1@gmail.com

MOB - 8780040272