E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital

Shrinivas R Raikar, Shivaraj B Patil, Venkata Rao Y, Raghuveer B.

Abstract
Background: Adverse drug reactions (ADRs) can lead to non-adherence to antiretroviral therapy (ART) and are also the major causes of hospitalization and higher cost of treatment.

Aims and Objectives: The aims of this study were to analyze the pattern of ADRs, causality, and severity among HIV-infected patients.

Materials and Methods: It was a retrospective analysis conducted over 1 year from January 2017 to December 2017. ADRs due to antiretroviral drugs (ARVs) were collected from the Government District Hospital, Nalgonda, as part of pharmacovigilance program and analyzed. The WHO-UMC scale was used for assessing the causality and Hartwig–Siegel scale for severity of reactions.

Results: A total of 113 ADRs due to ART were received. In that 68 were female patients. 83% ADRs were of mild grade of severity. Most of the ADRs were related to gastrointestinal system. Causality assessment of ADRs was probable in 62(54.9%) patients and possible in 51 (45.1%) patients.

Conclusion: Maximum number of ADRs was of mild nature suggesting that the ART is well tolerated among the patients. Further studies need to be conducted to fully understand the determinants of ADRs due to ART in a statistically significant manner.

Key words: Adverse Drug Reactions; Antiretroviral Therapy; Human Immunodeficiency Virus; Pharmacovigilance


 
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Pubmed Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1405-1408. doi:10.5455/njppp.2018.8.0620811072018


Web Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. http://www.njppp.com/?mno=301737 [Access: December 13, 2018]. doi:10.5455/njppp.2018.8.0620811072018


AMA (American Medical Association) Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1405-1408. doi:10.5455/njppp.2018.8.0620811072018



Vancouver/ICMJE Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol. (2018), [cited December 13, 2018]; 8(10): 1405-1408. doi:10.5455/njppp.2018.8.0620811072018



Harvard Style

Raikar, S. R., Patil, . S. B., Y, . V. R. & B, . R. (2018) An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol, 8 (10), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018



Turabian Style

Raikar, Shrinivas R, Shivaraj B Patil, Venkata Rao Y, and Raghuveer B. 2018. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018



Chicago Style

Raikar, Shrinivas R, Shivaraj B Patil, Venkata Rao Y, and Raghuveer B. "An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018



MLA (The Modern Language Association) Style

Raikar, Shrinivas R, Shivaraj B Patil, Venkata Rao Y, and Raghuveer B. "An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital." National Journal of Physiology, Pharmacy and Pharmacology 8.10 (2018), 1405-1408. Print. doi:10.5455/njppp.2018.8.0620811072018



APA (American Psychological Association) Style

Raikar, S. R., Patil, . S. B., Y, . V. R. & B, . R. (2018) An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018





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