E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats

Avinash Suresh Sarak, Jayshree Shriram Dawane, Vijaya Anil Pandit.

Abstract
Background: Inflammation is a protective response of the body to the harmful stimuli. Inflammation can be either acute or chronic, always associated pain, redness and loss of function. Vanilla planifolia (VP) is the aromatic plant, as per literature, it has anti-inflammatory activity, which has not been tested as per modern medicinal parameters. Non-steroidal anti-inflammatory drugs are commonly used for the treatment but have many adverse effects such as gastritis, hepatitis etc. Therefore, there is always a search for new safe drug.

Aim and Objectives: The aim of the study is to evaluate the anti-inflammatory activity of VP seeds in acute and chronic animal model of inflammation.

Materials and Methods: Rats weighing 150–200 g of either sex were included in the study. Acute Anti-inflammatory activity tested with carrageenan-induced paw edema and chronic with cotton pellet-induced granuloma model. Animals were divided into five groups – Gr-I Control, Gr-II Vehicle control, Gr-III Diclofenac sodium, Gr-IV (VPLD), Gr-V (VPHD). Drug treatment was given 1 h before carrageenan injection. Paw volume measured at different time interval with plethysmometer. In chronic model, drug treatment was given for 7 days after pellet implantation. On 8th day, pellets removed and dried in oven. Weight of wet and dry pellets from all the groups compared with vehicle control. Data obtained was analyzed with Graph pad prism 6.

Results: Reduction in paw volume started in all drug treated groups after 1 h of treatment. Paw volume was significantly reduced (P < 0.001) in group III, IV & V in 5 h. reached to near normal. In chronic model, VPLD showed decrease in wet pellet (P < 0.01) and dry pellet weight (P < 0.05) significantly. VPHD was more effective in reducing wet pellet (P < 0.001) and dry Pellet weight (P < 0.01). Similar results were seen on the left side.

Conclusion: VP seed extract showed promising anti-inflammatory effect in both models of inflammation.

Key words: Vanillin; Paw Edema; Plethysmometer; Anti-inflammatory


 
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How to Cite this Article
Pubmed Style

Sarak AS, Dawane JS, Pandit VA. Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. Natl J Physiol Pharm Pharmacol. Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021


Web Style

Sarak AS, Dawane JS, Pandit VA. Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. https://www.njppp.com/?mno=32179 [Access: May 02, 2022]. doi:10.5455/njppp.2022.12.12433202107122021


AMA (American Medical Association) Style

Sarak AS, Dawane JS, Pandit VA. Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. Natl J Physiol Pharm Pharmacol. Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021



Vancouver/ICMJE Style

Sarak AS, Dawane JS, Pandit VA. Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. Natl J Physiol Pharm Pharmacol, [cited May 02, 2022]; Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021



Harvard Style

Sarak, A. S., Dawane, . J. S. & Pandit, . V. A. (2022) Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. Natl J Physiol Pharm Pharmacol, Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021



Turabian Style

Sarak, Avinash Suresh, Jayshree Shriram Dawane, and Vijaya Anil Pandit. 2022. Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021



Chicago Style

Sarak, Avinash Suresh, Jayshree Shriram Dawane, and Vijaya Anil Pandit. "Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021



MLA (The Modern Language Association) Style

Sarak, Avinash Suresh, Jayshree Shriram Dawane, and Vijaya Anil Pandit. "Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology Online First: 19 Dec, 2021. Web. 02 May 2022 doi:10.5455/njppp.2022.12.12433202107122021



APA (American Psychological Association) Style

Sarak, A. S., Dawane, . J. S. & Pandit, . V. A. (2022) Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 19 Dec, 2021. doi:10.5455/njppp.2022.12.12433202107122021