E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice

Shokhista Tashmukhamedova, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, Lola Pulatova.

Abstract
Background: To date, there is little evidence in the literature about the effects of synthetic cannabinoids “spice” and antidepressants on the mammalian immune system.

Aims and Objectives: The study of the formation of immunoglobulin (Ig)G and IgM class antibodies to synthetic cannabinoids “spice” and antidepressants for a comparative assessment of the role of the class of antibodies in the detection of dependence on psychotropic drugs.

Materials and Methods: Conjugates were obtained with four antidepressants: Faverin, carbamazepine, sertraline, and fluoxetine and two synthetic cannabinoids of the “spice” type – AB-FUBINACA and ADB-CHMINACA in conjunction with the carrier protein-bovine serum albumin. The serological activity of synthesized conjugates based on the protein matrix was determined.

Results: Data were obtained on the determination of antibodies to the studied synthetic cannabinoids and antidepressants by enzyme-linked immunosorbent assay, and the immunoreactivity of mouse antibodies against heterologous haptens was established.

Conclusion: The article examines in detail the issues related to the comparative analysis of the formation of IgG and IgM antibodies to synthetic cannabinoids and antidepressants in mice in the experiment. It has been established that IgM antibodies play a significant role in the diagnosis of psychotropic substances.

Key words: Antibodies; Specific Immunoglobulin; Spice; Opiates; Barbiturates; Cannabinoids; L-Adrenaline; Dopamine Hydrochloride; Enzyme-linked Immunosorbent Assay; Haptens


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shokhista Tashmukhamedova
Articles by Svetlana Polyarush
Articles by Tamara Aripova
Articles by Farrukh Riskulov
Articles by Lola Pulatova
on Google
on Google Scholar
Article Statistics
 Viewed: 357
Downloaded: 13


How to Cite this Article
Pubmed Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. doi:10.5455/njppp.2020.10.01007202002032020


Web Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. http://www.njppp.com/?mno=73645 [Access: March 13, 2020]. doi:10.5455/njppp.2020.10.01007202002032020


AMA (American Medical Association) Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. doi:10.5455/njppp.2020.10.01007202002032020



Vancouver/ICMJE Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. doi:10.5455/njppp.2020.10.01007202002032020



Harvard Style

Tashmukhamedova, S., Polyarush, . S., Aripova, . T., Riskulov, . F. & Pulatova, . L. (2020) Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. doi:10.5455/njppp.2020.10.01007202002032020



Turabian Style

Tashmukhamedova, Shokhista, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, and Lola Pulatova. 2020. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. doi:10.5455/njppp.2020.10.01007202002032020



Chicago Style

Tashmukhamedova, Shokhista, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, and Lola Pulatova. "Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice." doi:10.5455/njppp.2020.10.01007202002032020



MLA (The Modern Language Association) Style

Tashmukhamedova, Shokhista, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, and Lola Pulatova. "Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice." doi:10.5455/njppp.2020.10.01007202002032020



APA (American Psychological Association) Style

Tashmukhamedova, S., Polyarush, . S., Aripova, . T., Riskulov, . F. & Pulatova, . L. (2020) Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. doi:10.5455/njppp.2020.10.01007202002032020





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Most Cited Articles
  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 11 times [Click to see citing articles]

  • Pattern of mobile phone usage and its effects on psychological health, sleep, and academic performance in students of a medical university
    Naveenta Gupta, Sonia Garg, Khushdeep Arora
    Natl J Physiol Pharm Pharmacol. 2016; 6(2): 132-139
    » Abstract & References » doi: 10.5455/njppp.2016.6.0311201599
    Cited : 11 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 11 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 10 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 7 times [Click to see citing articles]