E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma

Iram Shaifali, Neetu Gupta, Shalini Chandra, Kanupriya Agarwal.

Abstract
Background: Glaucoma is a chronic, progressive optic neuropathy which leads to optic nerve damage and loss of visual function. Elevated intraocular pressure (IOP) is the most important and only modifiable risk factor. Ocular hypotensive agents have the potential to lower the IOP and preserve vision.

Aims and Objectives: The aims of the study were to compare topical latanoprost eye drop and topical timolol eye drop as appropriate and cost-effective management of primary open-angle glaucoma (POAG).

Materials and Methods: A total of 70 newly diagnosed patients POAG who fulfilled the inclusion/exclusion criteria were enrolled and randomized into two groups. The first group L-Group was prescribed topical latanoprost 0.005% eye drop once daily, whereas the second group T-Group was prescribed topical timolol 0.5% eye drop twice a day. Final reduction in IOP was recorded after 3 months of treatment in both the groups. The cost-effectiveness was calculated as the cost of the drug per mmHg fall in IOP.

Results: In our study, the IOP lowering efficacy of latanoprost was found to be superior to timolol. In the latanoprost group, the mean reduction in IOP from baseline to final visit was 10.13 mmHg, whereas only 5.84 mmHg in the timolol group. The average cost-effective ratio was found to be Rs. 32.4/ mmHg and Rs. 6.16/mmHg for latanoprost and timolol, respectively. Hence, timolol proved to be more cost effective as compare to latanoprost.

Conclusion: Although latanoprost was found to be superior to timolol in reducing the IOP, yet because of its high cost the treatment should be started with timolol and latanoprost should only be used as an add-on therapy in cases not able to achieve target IOP by timolol monotherapy or in whom timolol is contraindicated.

Key words: Intraocular Pressure; Latanoprost; Timolol; Open Angle Glaucoma; Cost-effectiveness


 
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How to Cite this Article
Pubmed Style

Shaifali I, Gupta N, Chandra S, Agarwal K. A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. Natl J Physiol Pharm Pharmacol. 2020; 10(5): 400-404. doi:10.5455/njppp.2020.10.03056202018032020


Web Style

Shaifali I, Gupta N, Chandra S, Agarwal K. A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. http://www.njppp.com/?mno=90457 [Access: November 01, 2020]. doi:10.5455/njppp.2020.10.03056202018032020


AMA (American Medical Association) Style

Shaifali I, Gupta N, Chandra S, Agarwal K. A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. Natl J Physiol Pharm Pharmacol. 2020; 10(5): 400-404. doi:10.5455/njppp.2020.10.03056202018032020



Vancouver/ICMJE Style

Shaifali I, Gupta N, Chandra S, Agarwal K. A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. Natl J Physiol Pharm Pharmacol. (2020), [cited November 01, 2020]; 10(5): 400-404. doi:10.5455/njppp.2020.10.03056202018032020



Harvard Style

Shaifali, I., Gupta, . N., Chandra, . S. & Agarwal, . K. (2020) A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. Natl J Physiol Pharm Pharmacol, 10 (5), 400-404. doi:10.5455/njppp.2020.10.03056202018032020



Turabian Style

Shaifali, Iram, Neetu Gupta, Shalini Chandra, and Kanupriya Agarwal. 2020. A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. National Journal of Physiology, Pharmacy and Pharmacology, 10 (5), 400-404. doi:10.5455/njppp.2020.10.03056202018032020



Chicago Style

Shaifali, Iram, Neetu Gupta, Shalini Chandra, and Kanupriya Agarwal. "A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 400-404. doi:10.5455/njppp.2020.10.03056202018032020



MLA (The Modern Language Association) Style

Shaifali, Iram, Neetu Gupta, Shalini Chandra, and Kanupriya Agarwal. "A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma." National Journal of Physiology, Pharmacy and Pharmacology 10.5 (2020), 400-404. Print. doi:10.5455/njppp.2020.10.03056202018032020



APA (American Psychological Association) Style

Shaifali, I., Gupta, . N., Chandra, . S. & Agarwal, . K. (2020) A comparative study on the efficacy and cost-effectiveness of latanoprost and timolol in glaucoma. National Journal of Physiology, Pharmacy and Pharmacology, 10 (5), 400-404. doi:10.5455/njppp.2020.10.03056202018032020