E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals

Ravi Babu Katuri, Girwar Singh Gaur, Jaya Prakash Sahoo, Zachariah Bobby, Karthik Shanmugavel.

Abstract
Background: Evidences indicate altered circulating adipokine levels in obesity could increase the risk for cardiovascular disease (CVD). Hence, it is crucial to determine cardiovascular health by assessing heart rate variability (HRV) and its association with circulating adipokines.

Aim and Objectives: The aim of the study was to assess the adipokines level and its association with HRV in obese population.

Materials and Methods: A cross-sectional comparative study was conducted on 45 obese (body mass index [BMI] > 25–29.9 kg/m2) and 45 non-obese (BMI: 18.5–22.9 kg/m2) age-gender-matched participants. Lead-II electrocardiogram was recorded and HRV parameters were obtained. Biochemical parameters, that is, fasting blood glucose, fasting insulin, HOMA-IR, lipid profile, leptin, and adiponectin levels were estimated. Group comparisons were done by independent student’s t-test, whereas the association between the parameters was done by Pearson’s correlation using SPSS 20v. P < 0.05 was considered statistically significant.

Results: There was a significant increase in low frequency: high frequency (LF: HF) ratio (<0.001), fasting insulin (<0.001), HOMA-IR (<0.001), leptin (<0.001), Leptin-Adiponectin ratio (L/A ratio) (<0.001), total cholesterol (<0.001), triglycerides (<0.001), and low-density lipoproteins (<0.001), whereas significant decrease in total power (TP) of HRV (TP) (<0.001), adiponectin (<0.001), and high-density lipoproteins. A significant positive correlation between leptin, L/A ratio with LF: HF ratio (r = 0.793, P < 0.001) and a negative correlation with TP (–0.463, P < 0.001) was observed.

Conclusion: Altered adipokines and its association with HRV in obese individuals could be an indicator of CVD. Hence, the current study suggests that the L/A ratio might be considered as a biomarker for cardiovascular health in obese individuals.

Key words: Cardiovascular Disease Risk; Heart Rate Variability; Insulin Sensitivity; Obesity; Sympathovagal Imbalance


 
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How to Cite this Article
Pubmed Style

Katuri RB, Gaur GS, Sahoo JP, Bobby Z, Shanmugavel K. Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. doi:10.5455/njppp.2022.11.07238202123072021


Web Style

Katuri RB, Gaur GS, Sahoo JP, Bobby Z, Shanmugavel K. Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. http://www.njppp.com/?mno=95155 [Access: October 01, 2021]. doi:10.5455/njppp.2022.11.07238202123072021


AMA (American Medical Association) Style

Katuri RB, Gaur GS, Sahoo JP, Bobby Z, Shanmugavel K. Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. doi:10.5455/njppp.2022.11.07238202123072021



Vancouver/ICMJE Style

Katuri RB, Gaur GS, Sahoo JP, Bobby Z, Shanmugavel K. Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. doi:10.5455/njppp.2022.11.07238202123072021



Harvard Style

Katuri, R. B., Gaur, . G. S., Sahoo, . J. P., Bobby, . Z. & Shanmugavel, . K. (2022) Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. doi:10.5455/njppp.2022.11.07238202123072021



Turabian Style

Katuri, Ravi Babu, Girwar Singh Gaur, Jaya Prakash Sahoo, Zachariah Bobby, and Karthik Shanmugavel. 2022. Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. doi:10.5455/njppp.2022.11.07238202123072021



Chicago Style

Katuri, Ravi Babu, Girwar Singh Gaur, Jaya Prakash Sahoo, Zachariah Bobby, and Karthik Shanmugavel. "Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals." doi:10.5455/njppp.2022.11.07238202123072021



MLA (The Modern Language Association) Style

Katuri, Ravi Babu, Girwar Singh Gaur, Jaya Prakash Sahoo, Zachariah Bobby, and Karthik Shanmugavel. "Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals." doi:10.5455/njppp.2022.11.07238202123072021



APA (American Psychological Association) Style

Katuri, R. B., Gaur, . G. S., Sahoo, . J. P., Bobby, . Z. & Shanmugavel, . K. (2022) Altered circulating adipokines and heart rate variability: A biomarker for autonomic imbalance in obese individuals. doi:10.5455/njppp.2022.11.07238202123072021