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Original Research

Online Publishing Date:
16 / 09 / 2015

 


Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini.


Abstract
Background: Ganoderma lucidum, commonly referred to as Lingzhi in China, is a fungus that has been widely used through the centuries for the general promotion of health and longevity in Asian countries.

Aims and Objective: To determine the effects of subchronic exposure of PSP G. lucidum on renal function and renal histopathology feature in Rattus novergicus Wistar strain.

Materials and Methods: A total of 80 male and female Wistar rats, aged 2–3 months with a body weight of 200–300 g, were divided into four treatment groups: dose group 0 (control group), group PSP G. lucidum dose of 300, 600, and 1200 mg/kg for 90 days. Parameters measured were urea and creatinine levels and renal histopathology feature.

Result: From the research, the highest urea levels were found in the group in which female Wistar rats were treated with PSP dose of 300 mg/kg/day with an average concentration of urea of 33.2 mg/dL, whereas creatinine levels were found to be equally high on treatment with PSP dose of 1200, 600, and 300 mg/kg/day with an average concentration of urea of 0.3 mg/dL. On histopathological examination, no morphological abnormalities were found. The results of one-way analysis of variance test showed no significant difference at all PSP G. lucidum doses.

Conclusion: It is concluded that giving PSP G. lucidum in three variant doses does not cause dysfunction and histological damage to the renal function.

Key words: PSP Ganoderma lucidum; Subchronic Exposure; Urea; Creatinine; Renal Organ Histopathology


 
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How to Cite this Article
Pubmed Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 296-302. doi:10.5455/njppp.2015.5.0603201539

Web Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. https://www.njppp.com/?mno=181788 [Access: March 14, 2024]. doi:10.5455/njppp.2015.5.0603201539

AMA (American Medical Association) Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 296-302. doi:10.5455/njppp.2015.5.0603201539


Vancouver/ICMJE Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol. (2015), [cited March 14, 2024]; 5(4): 296-302. doi:10.5455/njppp.2015.5.0603201539


Harvard Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini (2015) Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol, 5 (4), 296-302. doi:10.5455/njppp.2015.5.0603201539


Turabian Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. 2015. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 296-302. doi:10.5455/njppp.2015.5.0603201539


Chicago Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. "Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 296-302. doi:10.5455/njppp.2015.5.0603201539


MLA (The Modern Language Association) Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini. "Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain." National Journal of Physiology, Pharmacy and Pharmacology 5.4 (2015), 296-302. Print. doi:10.5455/njppp.2015.5.0603201539


APA (American Psychological Association) Style

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini (2015) Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 296-302. doi:10.5455/njppp.2015.5.0603201539


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