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Online Publishing Date:
23 / 11 / 2015

 


Drug interaction and its implication in clinical practice and personalized medicine

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque.


Abstract
In personalized medicine, the appropriate drugs for an individual patient are selected based on the patient’s medical history, diagnostic testing, and genetic information for the purpose of minimizing drug interactions (DIs), side effects, and adverse drug reactions (ADRs) and of obtaining the maximum therapeutic benefit. The DI is one of the major problems of pharmacotherapy, which perhaps leads to adverse outcome or therapeutic failure if not properly addressed. In clinical practice, patient safety is likely to improve through the identification of frequently occurring DIs by pharmacist and notifying the other members of the health-care team. Recently, a software was introduced, which detects DIs with good precision; however, this software requires a constant update. Health-care professionals require adequate knowledge and skills on how to identify and avoid DIs to enable them complement the software assessment. Basically, DIs include drug–drug, drug–food, drug–herbal, and drug–disease interactions. These possibilities can be identified from chemical properties, pharmacokinetics, and pharmacodynamics of the drug, patient medical history, concomitant disease, or organ failure. Focusing on DIs will help to reduce drug-related problems, advance the evidence-based medicine, and improve the level of patient satisfaction. Adequate knowledge of drug DIs will enable the health-care professionals to individualize the patient treatment in order to get maximum therapeutic benefit. This script is aimed at describing the various classes of DIs, their causes, and their implications in clinical practice and patient safety.

Key words: Drug Interactions; Pharmacokinetics; Food; Herbal; Disease


 
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How to Cite this Article
Pubmed Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. Drug interaction and its implication in clinical practice and personalized medicine. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 343-349. doi:10.5455/njppp.2015.5.2005201557

Web Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. Drug interaction and its implication in clinical practice and personalized medicine. https://www.njppp.com/?mno=189303 [Access: March 14, 2024]. doi:10.5455/njppp.2015.5.2005201557

AMA (American Medical Association) Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. Drug interaction and its implication in clinical practice and personalized medicine. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 343-349. doi:10.5455/njppp.2015.5.2005201557


Vancouver/ICMJE Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. Drug interaction and its implication in clinical practice and personalized medicine. Natl J Physiol Pharm Pharmacol. (2015), [cited March 14, 2024]; 5(5): 343-349. doi:10.5455/njppp.2015.5.2005201557


Harvard Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque (2015) Drug interaction and its implication in clinical practice and personalized medicine. Natl J Physiol Pharm Pharmacol, 5 (5), 343-349. doi:10.5455/njppp.2015.5.2005201557


Turabian Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. 2015. Drug interaction and its implication in clinical practice and personalized medicine. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 343-349. doi:10.5455/njppp.2015.5.2005201557


Chicago Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. "Drug interaction and its implication in clinical practice and personalized medicine." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 343-349. doi:10.5455/njppp.2015.5.2005201557


MLA (The Modern Language Association) Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque. "Drug interaction and its implication in clinical practice and personalized medicine." National Journal of Physiology, Pharmacy and Pharmacology 5.5 (2015), 343-349. Print. doi:10.5455/njppp.2015.5.2005201557


APA (American Psychological Association) Style

Abdullahi Rabiu Abubakar, Bashir AZ Chedi, Khalid Garba Mohammed, Mainul Haque (2015) Drug interaction and its implication in clinical practice and personalized medicine. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 343-349. doi:10.5455/njppp.2015.5.2005201557


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