E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
05 / 07 / 2016

 


Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot.


Abstract
Background: Murraya koenigii, commonly known as karipatta or curry leaf, is analgesic and can be used effectively against inflammation and itching. The various pharmacological activities such as vasodilation, antimicrobial, antidiabetic, antiulcer, analgesic, phagocytic, and antioxidant activities of this plant have also been reported.

Aims and Objectives: To evaluate the anti-inflammatory and analgesic activity of aqueous extract of dried leaves of M. koenigii Linn. in male Wistar rats.

Materials and Methods: Adult male Wistar rats (100–150 g body weight) were used in this study. Aqueous extract of M. koenigii Linn. was used to evaluate acute anti-inflammatory and analgesic activity by plethysmometer and hot plate method by oral administration at doses of 100, 300, and 500 mg/kg body weight in healthy albino rats.

Result: In acute studies, the aqueous extract showed anti-inflammatory activity by significant reduction in the paw edema volume, in a dose-dependent manner when compared with the control and standard drug. Aqueous extract of M. koenigii Linn. significantly and dose-dependently reduced the number of acetic acid-induced writhing and significantly increased the latency of paw licking in hot plate method. Statistical analysis was carried out by one-way ANOVA, followed by Turkey's test.

Conclusion: Aqueous extract of M. koenigii Linn. possesses both anti-inflammatory and analgesic activity in a dose-dependent manner.

Key words: Murraya koenigii; Anti-inflammatory; Analgesic; Carrageenan; Paw Edema


 
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How to Cite this Article
Pubmed Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 286-290. doi:10.5455/njppp.2016.6.09122015123


Web Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. https://www.njppp.com/?mno=210380 [Access: March 15, 2024]. doi:10.5455/njppp.2016.6.09122015123


AMA (American Medical Association) Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 286-290. doi:10.5455/njppp.2016.6.09122015123



Vancouver/ICMJE Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol. (2016), [cited March 15, 2024]; 6(4): 286-290. doi:10.5455/njppp.2016.6.09122015123



Harvard Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot (2016) Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol, 6 (4), 286-290. doi:10.5455/njppp.2016.6.09122015123



Turabian Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. 2016. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 286-290. doi:10.5455/njppp.2016.6.09122015123



Chicago Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. "Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 286-290. doi:10.5455/njppp.2016.6.09122015123



MLA (The Modern Language Association) Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. "Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.." National Journal of Physiology, Pharmacy and Pharmacology 6.4 (2016), 286-290. Print. doi:10.5455/njppp.2016.6.09122015123



APA (American Psychological Association) Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot (2016) Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 286-290. doi:10.5455/njppp.2016.6.09122015123