E-ISSN 2231-3206 | ISSN 2320-4672
 

Case Report

Online Publishing Date:
17 / 07 / 2017

 


Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu.


Abstract
Leucovorin (LCV) acts as an essential coenzyme for nucleic acid synthesis and also it is an active metabolite of folic acid. LCV can be used to selectively “rescue” cells from the adverse effects of methotrexate (MTX). Here, we report a case of LCV-induced hypersensitivity reaction when used in combination with high dose MTX (HDMTX). We describe a 2-years-old female baby diagnosed with B-cell acute lymphoblastic leukemia on chemotherapy with pediatric berlinfrankfurt- munster protocol; she is on HDMTX and injection LCV. After initiation of LCV (folinic acid) at 42 h she was noted to have hypersensitivity reaction. Despite reaction to LCV is uncommon, one should be aware of the reactions that can be caused by LCV.

Key words: Leucovorin; High-dose Methotrexate; Acute Lymphatic Leukemia


 
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How to Cite this Article
Pubmed Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. Natl J Physiol Pharm Pharmacol. 2017; 7(9): 1007-1008. doi:10.5455/njppp.2017.7.0621407072017


Web Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. https://www.njppp.com/?mno=270197 [Access: March 14, 2024]. doi:10.5455/njppp.2017.7.0621407072017


AMA (American Medical Association) Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. Natl J Physiol Pharm Pharmacol. 2017; 7(9): 1007-1008. doi:10.5455/njppp.2017.7.0621407072017



Vancouver/ICMJE Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(9): 1007-1008. doi:10.5455/njppp.2017.7.0621407072017



Harvard Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu (2017) Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. Natl J Physiol Pharm Pharmacol, 7 (9), 1007-1008. doi:10.5455/njppp.2017.7.0621407072017



Turabian Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. 2017. Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. National Journal of Physiology, Pharmacy and Pharmacology, 7 (9), 1007-1008. doi:10.5455/njppp.2017.7.0621407072017



Chicago Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. "Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1007-1008. doi:10.5455/njppp.2017.7.0621407072017



MLA (The Modern Language Association) Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu. "Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report." National Journal of Physiology, Pharmacy and Pharmacology 7.9 (2017), 1007-1008. Print. doi:10.5455/njppp.2017.7.0621407072017



APA (American Psychological Association) Style

Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu (2017) Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report. National Journal of Physiology, Pharmacy and Pharmacology, 7 (9), 1007-1008. doi:10.5455/njppp.2017.7.0621407072017