E-ISSN 2231-3206 | ISSN 2320-4672
 

Case Report

Online Publishing Date:
04 / 09 / 2017

 


Cardiotoxicity associated with 5-flurouracil – A case series

Jisha S Das, Naveen Kumar Panicker.


Abstract
5-flurouracil (5-FU) is a frequently administered chemotherapeutic drug in various malignant neoplasms. We report four cases of cancer patients who were exposed to 5-FU and which resulted in cardio toxicity. Patients developed supraventricular tachycardia, sinus bradycardia, cardiomyopathy, and acute coronary vasospasms. In all cases, the events were reversible. Except in case of cardiomyopathy the chemotherapy was continued without any further issues. All the observed adverse drug reactions (ADR) were carefully studied and the causality was assessed using Naranjo ADR probability scale.

Key words: 5-Flurouracil; Cardiotoxicity; Cardiomyopathy


 
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Pubmed Style

Jisha S Das, Naveen Kumar Panicker. Cardiotoxicity associated with 5-flurouracil – A case series. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 149-151. doi:10.5455/njppp.2018.8.0726902082017


Web Style

Jisha S Das, Naveen Kumar Panicker. Cardiotoxicity associated with 5-flurouracil – A case series. https://www.njppp.com/?mno=273037 [Access: March 15, 2024]. doi:10.5455/njppp.2018.8.0726902082017


AMA (American Medical Association) Style

Jisha S Das, Naveen Kumar Panicker. Cardiotoxicity associated with 5-flurouracil – A case series. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 149-151. doi:10.5455/njppp.2018.8.0726902082017



Vancouver/ICMJE Style

Jisha S Das, Naveen Kumar Panicker. Cardiotoxicity associated with 5-flurouracil – A case series. Natl J Physiol Pharm Pharmacol. (2018), [cited March 15, 2024]; 8(1): 149-151. doi:10.5455/njppp.2018.8.0726902082017



Harvard Style

Jisha S Das, Naveen Kumar Panicker (2018) Cardiotoxicity associated with 5-flurouracil – A case series. Natl J Physiol Pharm Pharmacol, 8 (1), 149-151. doi:10.5455/njppp.2018.8.0726902082017



Turabian Style

Jisha S Das, Naveen Kumar Panicker. 2018. Cardiotoxicity associated with 5-flurouracil – A case series. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 149-151. doi:10.5455/njppp.2018.8.0726902082017



Chicago Style

Jisha S Das, Naveen Kumar Panicker. "Cardiotoxicity associated with 5-flurouracil – A case series." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 149-151. doi:10.5455/njppp.2018.8.0726902082017



MLA (The Modern Language Association) Style

Jisha S Das, Naveen Kumar Panicker. "Cardiotoxicity associated with 5-flurouracil – A case series." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 149-151. Print. doi:10.5455/njppp.2018.8.0726902082017



APA (American Psychological Association) Style

Jisha S Das, Naveen Kumar Panicker (2018) Cardiotoxicity associated with 5-flurouracil – A case series. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 149-151. doi:10.5455/njppp.2018.8.0726902082017