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Online Publishing Date:
20 / 10 / 2021

 


Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?

Bhanu R, Vinutha Shankar M S, Pramodh V.


Abstract
Background: P300 event-related potentials (ERPs) is an electrophysiologic marker of cognitive ability which closely reflects cognitive functions. Type 2 Diabetes mellitus (T2DM) causes many complications. Diabetes mellitus-induced damage to the central nervous system is a key focus of research. Latest magnetic resonance imaging evidence suggested that the changes in anatomy of brain is more rapidly seen in males than in females. This study was carried out to study the gender variations in P300 latency and Mini Mental State Examination (MMSE).

Aim and Objective: To study the influence of gender on MMSE score as well as P300 ERP.

Materials and Methods: 30 diagnosed Type 2 Diabetics aged above 40 years, with more than 2 years duration of diabetes were included in this study. MMSE questionnaire was administered to each diabetic and P300 was recorded using RMS EMG EP MARK 2 machine in all the diabetics.

Results: The P300 ERP of male diabetics was prolonged significantly with mean ± standard deviation (SD) of (347.01 ± 31.55) whereas female diabetics had a mean ± SD of (318.26 ± 28.22; P = 0.014) and no significant difference was found between the mean MMSE scores of male diabetics (26.06 ± 1.38) and female diabetics (26.13 ± 1.30).

Conclusion: The change in P300 ERP is swifter in males when compared with females in the middle to old age. Compared to MMSE, P300 Latency is a sensitive electrophysiological tool for diagnosing early cognitive deterioration in T2DM.

Key words: Event-related Potentials; Gender; Cognitive Deterioration; Type 2 Diabetes Mellitus; Mini Mental State Examination


 
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Pubmed Style

R B, S VSM, V P. Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. Natl J Physiol Pharm Pharmacol. 2022; 12(4): 468-471. doi:10.5455/njppp.2022.12.06200202126092021

Web Style

R B, S VSM, V P. Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. https://www.njppp.com/?mno=88649 [Access: March 15, 2024]. doi:10.5455/njppp.2022.12.06200202126092021

AMA (American Medical Association) Style

R B, S VSM, V P. Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. Natl J Physiol Pharm Pharmacol. 2022; 12(4): 468-471. doi:10.5455/njppp.2022.12.06200202126092021


Vancouver/ICMJE Style

R B, S VSM, V P. Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. Natl J Physiol Pharm Pharmacol. (2022), [cited March 15, 2024]; 12(4): 468-471. doi:10.5455/njppp.2022.12.06200202126092021


Harvard Style

R, B., S, . V. S. M. & V, . P. (2022) Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. Natl J Physiol Pharm Pharmacol, 12 (4), 468-471. doi:10.5455/njppp.2022.12.06200202126092021


Turabian Style

R, Bhanu, Vinutha Shankar M S, and Pramodh V. 2022. Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. National Journal of Physiology, Pharmacy and Pharmacology, 12 (4), 468-471. doi:10.5455/njppp.2022.12.06200202126092021


Chicago Style

R, Bhanu, Vinutha Shankar M S, and Pramodh V. "Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 468-471. doi:10.5455/njppp.2022.12.06200202126092021


MLA (The Modern Language Association) Style

R, Bhanu, Vinutha Shankar M S, and Pramodh V. "Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?." National Journal of Physiology, Pharmacy and Pharmacology 12.4 (2022), 468-471. Print. doi:10.5455/njppp.2022.12.06200202126092021


APA (American Psychological Association) Style

R, B., S, . V. S. M. & V, . P. (2022) Does gender influence P300 latency and mini mental state examination score in type 2 diabetes mellitus patients?. National Journal of Physiology, Pharmacy and Pharmacology, 12 (4), 468-471. doi:10.5455/njppp.2022.12.06200202126092021


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