E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
09 / 11 / 2022

 


Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study

Bhuvaneswari S, Suresh Bhalaji S, Sarath Babu Kurra, Nasrin Nisha A.


Abstract
Background: This study was conducted to evaluate the effect of various oral hypoglycemic agents in the control of plasma blood glucose levels among Type 2 diabetes mellitus (T2DM) patients.

Aims and Objectives: This study is aimed to evaluate the blood glucose controlling efficacy of various oral hypoglycemic drugs in T2DM patients.

Materials and Methods: This randomized and control study was conducted among the cases attending Department of General Medicine at Research cell of Chennai Medical College Hospital and Research Centre, during the period of June 2014 to July 2015. A total of 180 cases were randomly allotted to six groups. Group I was treated with Glibenclamide, Group-II was treated with Glibenclamide + Sitagliptin, Group-III was treated with Glibenclamide + Vildagliptin, Group-IV was treated with Metformin, Group-V was treated with Metformin + Sitagliptin, and Group-VI was treated with Metformin + Vildagliptin. Fasting, postprandial, and glycated hemoglobin (HbA1c) levels were assessed before and at 4, 8, and 12th weeks and the data were analyzed using Statistical Package for the Social Sciences.

Results: Fasting and postprandial sugars were significantly reduced in Group V and Group VI during 4th, 8th, and 12th weeks. However, HbA1c levels were significantly reduced after 12 weeks of treatment in Group III, Group V, and Group VI.

Conclusion: We conclude that metformin in combination with either Vildagliptin or Sitagliptin can help to reduce fasting, postprandial, and HbA1c levels (both in short-term and in long-term); however, Glibenclamide along with Vildagliptin could reduce only HbA1c levels (long-term alone).

Key words: Glycemic Levels; Vildagliptin; Sitagliptin; Oral Hypoglycemic Agents; Hypoglycemia; Diabetes Mellitus


 
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How to Cite this Article
Pubmed Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022


Web Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. https://www.njppp.com/?mno=118286 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.094732022002112022


AMA (American Medical Association) Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022



Vancouver/ICMJE Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(6): 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022



Harvard Style

S, B., S, . S. B., Kurra, . S. B. & A, . N. N. (2023) Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol, 13 (6), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022



Turabian Style

S, Bhuvaneswari, Suresh Bhalaji S, Sarath Babu Kurra, and Nasrin Nisha A. 2023. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022



Chicago Style

S, Bhuvaneswari, Suresh Bhalaji S, Sarath Babu Kurra, and Nasrin Nisha A. "Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022



MLA (The Modern Language Association) Style

S, Bhuvaneswari, Suresh Bhalaji S, Sarath Babu Kurra, and Nasrin Nisha A. "Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study." National Journal of Physiology, Pharmacy and Pharmacology 13.6 (2023), 1140-1145. Print. doi:10.5455/njppp.2023.13.094732022002112022



APA (American Psychological Association) Style

S, B., S, . S. B., Kurra, . S. B. & A, . N. N. (2023) Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022