Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment

Vandana Shridhar Pulate; Rahul R Kunkulol; Sandeep P Narwane; Sonali N Tambe

doi:10.5455/njppp.2022.12.01015202211012022

2023, Vol: 13, Issue: 5

13/5Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1339-1343

doi: 10.5455/njppp.2022.12.01015202211012022

Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment

Vandana Shridhar Pulate, Rahul R Kunkulol, Sandeep P Narwane, Sonali N Tambe.

Abstract
Background: The prevalence of hypertension is rapidly increasing among both rural and urban populations and is a matter of concern in India. L-Arginine serves as a principle substrate for nitric oxide production which is a potent vasodilator.

Aims and Objectives: This study was designed to determine the effects of oral L-arginine on blood pressure in hypertensive patients on antihypertensive drugs.

Materials and Methods: This was a randomized clinical trial, registration in Clinical Trial Registry of India (CTRI) Registration number: CTRI/2019/03/018026. All patients with hypertension visiting the medicine outpatient department of Dr. Vitthalrao Vikhe Patil Pravara Rural Hospital, Loni, were included in the study. Study participants were randomized into intervention group (I group) and control group (C group). The I group includes 74 participants and the C group includes 75 participants. The I group received antihypertensive therapy along with add-on L-arginine oral supplementation for 14 days. The C group received only standard antihypertensive therapy and had followed up similar to that of the participants of the I group.

Results: The baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the I group and C group was statistically non-significant as analyzed by unpaired t-test, whereas in the I group, there was a significant decrease in SBP and DBP on the 1st, 2nd, and 3rd follow-up visits compared to the C group (Friedman test).

Conclusion: The findings of the present study showed that add-on L-arginine supplementation at a dose of 3 g/d (L-arginine 5 g sachet) for 2 weeks in patients of hypertension resulted in significant decrease in the SBP and DBP.

Key words: Blood Pressure; Hypertensive Patients; L-Arginine; Nitric Oxide

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Vandana Shridhar Pulate Articles by Rahul R Kunkulol Articles by Sandeep P Narwane Articles by Sonali N Tambe
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Pulate VS, Kunkulol RR, Narwane SP, Tambe SN. Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

Web Style

Pulate VS, Kunkulol RR, Narwane SP, Tambe SN. Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. https://www.njppp.com/?mno=140946 [Access: May 01, 2023]. doi:10.5455/njppp.2022.12.01015202211012022

AMA (American Medical Association) Style

Pulate VS, Kunkulol RR, Narwane SP, Tambe SN. Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

Vancouver/ICMJE Style

Pulate VS, Kunkulol RR, Narwane SP, Tambe SN. Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. Natl J Physiol Pharm Pharmacol. (2022), [cited May 01, 2023]; 12(9): 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

Harvard Style

Pulate, V. S., Kunkulol, . R. R., Narwane, . S. P. & Tambe, . S. N. (2022) Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. Natl J Physiol Pharm Pharmacol, 12 (9), 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

Turabian Style

Pulate, Vandana Shridhar, Rahul R Kunkulol, Sandeep P Narwane, and Sonali N Tambe. 2022. Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

Chicago Style

Pulate, Vandana Shridhar, Rahul R Kunkulol, Sandeep P Narwane, and Sonali N Tambe. "Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

MLA (The Modern Language Association) Style

Pulate, Vandana Shridhar, Rahul R Kunkulol, Sandeep P Narwane, and Sonali N Tambe. "Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment." National Journal of Physiology, Pharmacy and Pharmacology 12.9 (2022), 1339-1343. Print. doi:10.5455/njppp.2022.12.01015202211012022

APA (American Psychological Association) Style

Pulate, V. S., Kunkulol, . R. R., Narwane, . S. P. & Tambe, . S. N. (2022) Effect of add-on L-arginine on blood pressure in hypertensive patients on antihypertensive treatment. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1339-1343. doi:10.5455/njppp.2022.12.01015202211012022

Author Login Reviewer Login About Publisher Editorial Policies Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information



Copyright © 2023 National Journal of Physiology, Pharmacy and Pharmacology All Rights Reserved. Subject to change without notice from or liability to National Journal of Physiology, Pharmacy and Pharmacology. For best results, please use Internet Explorer or Google Chrome	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272

Contact Information

How to cite this article