E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 15 Jul 2024
 


Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study

Alok Dixit, Devesh Pandey, Nasreen Fatma Khan, Chandraveer Singh, Asha Pathak, Ramakant Yadav.


Abstract
Background: About 9% of the overall population suffers from migraine headaches, with a female majority. For the prevention of migraines, the two most often prescribed drugs are topiramate (TPM) and flunarizine. Regarding TPM and flunarizine’s long-term efficacy, safety, and adverse effects on migraine prevention, little is known. To evaluate the effectiveness of flunarizine against TPM in migraine prophylaxis and its impact on psychomotor ability, the current study was designed.

Aims and Objectives: The aim of the study was to compare the efficacy of flunarizine and TPM in the prophylaxis of migraine and to assess change in the psychomotor ability of the brain using different psychomotor analysis scoring systems.

Materials and Methods: A comparative, open-label, and prospective study was carried out on patients with chronic migraine from the outpatient department of the neurology department at Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, with flunarizine and TPM treatment (n = 20/group) for 2 months. Data regarding patient’s scores of headache severity on the Visual Analogue Scale (VAS), digit later substitution test, 6 letter cancellation test, digit span test, mathematical ability test, and flicker fusion apparatus test were recorded and analyzed.

Results: When compared to the baseline, the mean±standard deviation pain severity score on the VAS was 2.9 ± 0.8 in the flunarizine group and 3.7 ± 1.4 in the TPM group, with a P < 0.001. Furthermore, the flunarizine group showed less decline in performances in the scores of each psychomotor test as compared with the scores of the TPM treatment group when baseline values were compared at 1 and 2 months.

Conclusion: Flunarizine is well tolerated, has a better safety profile, and has less cognitive decline as compared to TPM.

Key words: Chronic Migraine; Visual Analogue Scale; Flicker Fusion Apparatus Test


 
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How to Cite this Article
Pubmed Style

Dixit A, Pandey D, Khan NF, Singh C, Pathak A, Yadav R. Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024


Web Style

Dixit A, Pandey D, Khan NF, Singh C, Pathak A, Yadav R. Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. https://www.njppp.com/?mno=200059 [Access: November 01, 2024]. doi:10.5455/njppp.2024.14.05194202401072024


AMA (American Medical Association) Style

Dixit A, Pandey D, Khan NF, Singh C, Pathak A, Yadav R. Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024



Vancouver/ICMJE Style

Dixit A, Pandey D, Khan NF, Singh C, Pathak A, Yadav R. Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. Natl J Physiol Pharm Pharmacol. (2024), [cited November 01, 2024]; 14(10): 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024



Harvard Style

Dixit, A., Pandey, . D., Khan, . N. F., Singh, . C., Pathak, . A. & Yadav, . R. (2024) Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. Natl J Physiol Pharm Pharmacol, 14 (10), 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024



Turabian Style

Dixit, Alok, Devesh Pandey, Nasreen Fatma Khan, Chandraveer Singh, Asha Pathak, and Ramakant Yadav. 2024. Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024



Chicago Style

Dixit, Alok, Devesh Pandey, Nasreen Fatma Khan, Chandraveer Singh, Asha Pathak, and Ramakant Yadav. "Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024



MLA (The Modern Language Association) Style

Dixit, Alok, Devesh Pandey, Nasreen Fatma Khan, Chandraveer Singh, Asha Pathak, and Ramakant Yadav. "Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study." National Journal of Physiology, Pharmacy and Pharmacology 14.10 (2024), 2198-2203. Print. doi:10.5455/njppp.2024.14.05194202401072024



APA (American Psychological Association) Style

Dixit, A., Pandey, . D., Khan, . N. F., Singh, . C., Pathak, . A. & Yadav, . R. (2024) Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2198-2203. doi:10.5455/njppp.2024.14.05194202401072024