Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study

Amulya Shetkar; Parmeshwarappa K Dhanurkar; Lokesh Patil; Gajanan P Kulkarni; Savitha A

doi:10.5455/njppp.2024.14.06245202418062024

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Online Published: 27 Jun 2024

Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2151-2154

doi: 10.5455/njppp.2024.14.06245202418062024

Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study

Amulya Shetkar, Parmeshwarappa K Dhanurkar, Lokesh Patil, Gajanan P Kulkarni, Savitha A.

Abstract
Background: A urinary tract infection (UTI) occurs when germs infiltrate a sterile urine system. At 18/1000 in the general population, UTIs have been reported to be one of the most common infections to date. As antimicrobial abuse has led to resistance among microorganisms, the sensitivity pattern of the microorganisms isolated from urine culture helps clinician to choose the best antimicrobial agent for the treatment of UTI.

Aim and Objectives: (i) The study aimed to identify the microbiological spectrum of organisms isolated from urinary culture and (ii) to assess the antibiotic sensitivity and resistance pattern of the organisms isolated.

Materials and Methods: A prospective observational study was conducted between August 2022 and July 2023. The urine samples were analyzed for bacterial growth, antimicrobial sensitivity, and resistance patterns.

Results: During the study period, 175 urine samples were sent for culture and sensitivity testing. Out of which 49 showed positive growth. Escherichia coli 25 (51%) was the most commonly isolated organism, followed by Klebsiella 16 (33 %) and Staphylococcus aureus 8 (16%). E. coli was found highly sensitive to imipenem, followed by nitrofurantoin, and was found highly resistant to ceftriaxone and ciprofloxacin. Klebsiella was found highly sensitive to nitrofurantoin and imipenem and was found highly resistant to amoxycillin, norfloxacin, and ciprofloxacin. S. aureus was found highly sensitive to imipenem, followed by gentamicin, and was found highly resistant to amikacin, amoxycillin, and amoxiclav.

Conclusion: Ceftriaxone, ciprofloxacin, norfloxacin, amikacin, amoxycillin, and amoxiclav were highly resistant antimicrobials, while imipenem and nitrofurantoin were found to be very sensitive. Therefore, to optimize the therapeutic outcome and curb the spread of drug-resistant strains, clinicians must use these antimicrobial agents judiciously.

Key words: Urinary Tract Infection; Antimicrobial Resistance; Culture and Sensitivity

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How to Cite this Article

Pubmed Style

Shetkar A, Dhanurkar PK, Patil L, Kulkarni GP, A S. Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

Web Style

Shetkar A, Dhanurkar PK, Patil L, Kulkarni GP, A S. Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. https://www.njppp.com/?mno=204495 [Access: January 17, 2025]. doi:10.5455/njppp.2024.14.06245202418062024

AMA (American Medical Association) Style

Shetkar A, Dhanurkar PK, Patil L, Kulkarni GP, A S. Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

Vancouver/ICMJE Style

Shetkar A, Dhanurkar PK, Patil L, Kulkarni GP, A S. Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. Natl J Physiol Pharm Pharmacol. (2024), [cited January 17, 2025]; 14(10): 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

Harvard Style

Shetkar, A., Dhanurkar, . P. K., Patil, . L., Kulkarni, . G. P. & A, . S. (2024) Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. Natl J Physiol Pharm Pharmacol, 14 (10), 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

Turabian Style

Shetkar, Amulya, Parmeshwarappa K Dhanurkar, Lokesh Patil, Gajanan P Kulkarni, and Savitha A. 2024. Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

Chicago Style

Shetkar, Amulya, Parmeshwarappa K Dhanurkar, Lokesh Patil, Gajanan P Kulkarni, and Savitha A. "Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

MLA (The Modern Language Association) Style

Shetkar, Amulya, Parmeshwarappa K Dhanurkar, Lokesh Patil, Gajanan P Kulkarni, and Savitha A. "Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study." National Journal of Physiology, Pharmacy and Pharmacology 14.10 (2024), 2151-2154. Print. doi:10.5455/njppp.2024.14.06245202418062024

APA (American Psychological Association) Style

Shetkar, A., Dhanurkar, . P. K., Patil, . L., Kulkarni, . G. P. & A, . S. (2024) Evaluation and analysis of resistance to antimicrobial agents used in the treatment of urinary tract infection at tertiary care hospital: A culture and sensitivity-based study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2151-2154. doi:10.5455/njppp.2024.14.06245202418062024

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