E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 18 Jul 2024
 


Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom

Soma Bose, Sharmila Gupta, Sneha Maity.


Abstract
Background: Colistin is an antibiotic with lipophilic and hydrophilic properties, effective against Enterobacterales and non-fermenter bacteria. Due to the emergence of multidrug-resistant Gram-negative bacilli, colistin is being once again reintroduced as a last resort for their treatment. Resistance is caused by mutations and some are plasmid-mediated.

Aims and Objectives: The aim of the study was to determine antibiotic resistance patterns in Gram-negative bacilli and to detect colistin susceptibility patterns in multidrug-resistant Enterobacterales and Pseudomonas aeruginosa.

Materials and Methods: This prospective cross-sectional study was carried out in the Department of Microbiology, Calcutta National Medical College and Hospital, using standard laboratory protocol and colistin susceptibility was determined by colistin broth disk elution (CBDE) method.

Results: Out of a total of 80 patients infected with MDR isolates, 63.75% were male and 36.25% were female. The most common age group affected was 41–60 years. Multidrugresistant (MDR) bacteria were most commonly isolated from urine samples, and Klebsiella pneumoniae was the most common MDR bacteria isolated. Overall, colistin resistance was 7.5% and it was found most commonly in K. pneumoniae. The use of broad-spectrum antibiotics was the most common risk factor for the emergence of MDR bacterial infections, including colistin resistance.

Conclusion: The present study detects colistin resistance using a simple method – “CBDE test” which can be done in resource-poor settings and can guide clinicians to rationally use the medication as it may be used as an alternative treatment option for “Super bugs” and can even be used as the “last resort” in certain scenario.

Key words: Colistin; Colistin Broth Disk Elution; Multidrug-Resistant; Enterobacterales; Pseudomonas aeruginosa


 
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How to Cite this Article
Pubmed Style

Bose S, Gupta S, Maity S. Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024


Web Style

Bose S, Gupta S, Maity S. Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. https://www.njppp.com/?mno=208081 [Access: November 02, 2024]. doi:10.5455/njppp.2024.14.07273202407072024


AMA (American Medical Association) Style

Bose S, Gupta S, Maity S. Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024



Vancouver/ICMJE Style

Bose S, Gupta S, Maity S. Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. Natl J Physiol Pharm Pharmacol. (2024), [cited November 02, 2024]; 14(10): 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024



Harvard Style

Bose, S., Gupta, . S. & Maity, . S. (2024) Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. Natl J Physiol Pharm Pharmacol, 14 (10), 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024



Turabian Style

Bose, Soma, Sharmila Gupta, and Sneha Maity. 2024. Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024



Chicago Style

Bose, Soma, Sharmila Gupta, and Sneha Maity. "Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024



MLA (The Modern Language Association) Style

Bose, Soma, Sharmila Gupta, and Sneha Maity. "Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom." National Journal of Physiology, Pharmacy and Pharmacology 14.10 (2024), 2215-2219. Print. doi:10.5455/njppp.2024.14.07273202407072024



APA (American Psychological Association) Style

Bose, S., Gupta, . S. & Maity, . S. (2024) Increasing colistin resistance among multidrug-resistant isolates in the recent era – An impending doom. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2215-2219. doi:10.5455/njppp.2024.14.07273202407072024