Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters

Protik Mondal; Bhawna Bhutoria Jain; Sourav Kumar Ghosh; Ayandip Nandi

doi:10.5455/njppp.2022.12.11412202124112021

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Original Research
Online Published: 01 Dec 2021

Natl J Physiol Pharm Pharmacol. 2022; 12(6): 787-792

doi: 10.5455/njppp.2022.12.11412202124112021

Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters

Protik Mondal, Bhawna Bhutoria Jain, Sourav Kumar Ghosh, Ayandip Nandi.

Cited By:2

Abstract
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Tumor budding, defined by the presence of five or less tumor cell cluster in the invasive front of tumor, is a strong, reproducible, and independent prognostic marker of the biological aggressiveness of the tumor.

Aim and Objective: The present study was conducted to assess the correlation of clinicopathological parameter with tumor budding in CRC.

Materials and Methods: Sixty patients presenting with colectomy specimens with known histological diagnosis of colorectal adenocarcinoma were included in the study. Histological examination with hematoxylene and eosin stain and immunohistochemistry with pancytokeratin (Pan-CK) was performed in equivocal cases. Tumor budding was counted and scored as per international tumor budding consensus conference, 2016, recommended criteria. Tumor budding was correlated with other relevant clinicopathological parameters.

Results: The age distribution ranged from 19 to 78 years with a peak incidence in the age group of 4150 years (31.7%). Low-grade tumor budding was seen in 20%, intermediate grade budding in 16.7%, and high-grade tumor budding in 63.3%. No correlation could be established between age, sex, site, size of tumor, lymphovascular invasion, histological grade, and budding intensity. However, association between tumor budding and nodal involvement, perineural invasion and higher American Joint Committee on Cancer stage has been found to be statistically significant in this study.

Conclusions: Tumor budding is emerging to be a promising and powerful predictor of nodal metastasis and a higher stage of the tumor. Immunohistochemistry with Pan-CK can aid in the grading of tumor budding and buid consensus.

Key words: Colorectal Carcinoma; Immunohistochemistry; International Tumor Budding Consensus Conference Criteria; Pancytokeratin; Tumor, Node, Metastasis Staging; Tumor Budding

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Pubmed Style

Mondal P, Jain BB, Ghosh SK, Nandi A. Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. Natl J Physiol Pharm Pharmacol. 2022; 12(6): 787-792. doi:10.5455/njppp.2022.12.11412202124112021

Web Style

Mondal P, Jain BB, Ghosh SK, Nandi A. Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. https://www.njppp.com/?mno=2555 [Access: January 18, 2025]. doi:10.5455/njppp.2022.12.11412202124112021

AMA (American Medical Association) Style

Mondal P, Jain BB, Ghosh SK, Nandi A. Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. Natl J Physiol Pharm Pharmacol. 2022; 12(6): 787-792. doi:10.5455/njppp.2022.12.11412202124112021

Vancouver/ICMJE Style

Mondal P, Jain BB, Ghosh SK, Nandi A. Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. Natl J Physiol Pharm Pharmacol. (2022), [cited January 18, 2025]; 12(6): 787-792. doi:10.5455/njppp.2022.12.11412202124112021

Harvard Style

Mondal, P., Jain, . B. B., Ghosh, . S. K. & Nandi, . A. (2022) Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. Natl J Physiol Pharm Pharmacol, 12 (6), 787-792. doi:10.5455/njppp.2022.12.11412202124112021

Turabian Style

Mondal, Protik, Bhawna Bhutoria Jain, Sourav Kumar Ghosh, and Ayandip Nandi. 2022. Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. National Journal of Physiology, Pharmacy and Pharmacology, 12 (6), 787-792. doi:10.5455/njppp.2022.12.11412202124112021

Chicago Style

Mondal, Protik, Bhawna Bhutoria Jain, Sourav Kumar Ghosh, and Ayandip Nandi. "Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 787-792. doi:10.5455/njppp.2022.12.11412202124112021

MLA (The Modern Language Association) Style

Mondal, Protik, Bhawna Bhutoria Jain, Sourav Kumar Ghosh, and Ayandip Nandi. "Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters." National Journal of Physiology, Pharmacy and Pharmacology 12.6 (2022), 787-792. Print. doi:10.5455/njppp.2022.12.11412202124112021

APA (American Psychological Association) Style

Mondal, P., Jain, . B. B., Ghosh, . S. K. & Nandi, . A. (2022) Histopathological study of tumor budding in colorectal carcinoma and its correlation with clinicopathological parameters. National Journal of Physiology, Pharmacy and Pharmacology, 12 (6), 787-792. doi:10.5455/njppp.2022.12.11412202124112021

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