Cardioprotective function of progesterone: A new perspective

Asha Anand Dharwadkar; Raghuram Ramkumar Chitterusu; Anand Rajendra Dharwadkar; Bindu Balakrishnan Chenmarathy; Kavitarati Anand Dharwadkar

doi:10.5455/njppp.2017.7.0927404102016

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Review Article
Online Published: 25 Oct 2016

Natl J Physiol Pharm Pharmacol. 2017; 7(2): 136-142

doi: 10.5455/njppp.2017.7.0927404102016

Cardioprotective function of progesterone: A new perspective

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar.

Cited By:4

Abstract
Cardioprotective mechanism in females during reproductive phase is unclear. New perspective explains cardioprotective function of progesterone. Progesterone, the intermediary metabolic product in synthesis of steroid hormones, with t/2 of 30 min, stimulates respiratory center inducing respiratory alkalosis in turn lowers plasma ionic calcium. This results in decreased blood coagulability and cardiac contractility along with smooth muscle relaxation. Vascular smooth muscle relaxation, leading to generalized vasodilatation causes better tissue perfusion resulting in diminished erythropoietin, and erythrocyte count. This reduces blood viscosity and afterload on the heart. Cardiac contractility remains balanced due to opposing influences of decreased plasma ionic calcium and raised basal body temperature. On sudden withdrawal of progesterone, as during premenstrual, postpartum and postmenopausal periods, cardioprotective changes are reversed. The awareness helps to build better body buffer system, aiming to correct acid-base imbalance, during expected fluctuations of progesterone.

Key words: Respiratory Alkalosis; Muscle; Smooth; Vascular; Perimenopause; Progesterone; Vasodilation

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How to Cite this Article

Pubmed Style

Dharwadkar AA, Chitterusu RR, Dharwadkar AR, Chenmarathy BB, Dharwadkar KA. Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 136-142. doi:10.5455/njppp.2017.7.0927404102016

Web Style

Dharwadkar AA, Chitterusu RR, Dharwadkar AR, Chenmarathy BB, Dharwadkar KA. Cardioprotective function of progesterone: A new perspective. https://www.njppp.com/?mno=242818 [Access: November 02, 2025]. doi:10.5455/njppp.2017.7.0927404102016

AMA (American Medical Association) Style

Dharwadkar AA, Chitterusu RR, Dharwadkar AR, Chenmarathy BB, Dharwadkar KA. Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 136-142. doi:10.5455/njppp.2017.7.0927404102016

Vancouver/ICMJE Style

Dharwadkar AA, Chitterusu RR, Dharwadkar AR, Chenmarathy BB, Dharwadkar KA. Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol. (2017), [cited November 02, 2025]; 7(2): 136-142. doi:10.5455/njppp.2017.7.0927404102016

Harvard Style

Dharwadkar, A. A., Chitterusu, . R. R., Dharwadkar, . A. R., Chenmarathy, . B. B. & Dharwadkar, . K. A. (2017) Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol, 7 (2), 136-142. doi:10.5455/njppp.2017.7.0927404102016

Turabian Style

Dharwadkar, Asha Anand, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, and Kavitarati Anand Dharwadkar. 2017. Cardioprotective function of progesterone: A new perspective. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 136-142. doi:10.5455/njppp.2017.7.0927404102016

Chicago Style

Dharwadkar, Asha Anand, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, and Kavitarati Anand Dharwadkar. "Cardioprotective function of progesterone: A new perspective." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 136-142. doi:10.5455/njppp.2017.7.0927404102016

MLA (The Modern Language Association) Style

Dharwadkar, Asha Anand, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, and Kavitarati Anand Dharwadkar. "Cardioprotective function of progesterone: A new perspective." National Journal of Physiology, Pharmacy and Pharmacology 7.2 (2017), 136-142. Print. doi:10.5455/njppp.2017.7.0927404102016

APA (American Psychological Association) Style

Dharwadkar, A. A., Chitterusu, . R. R., Dharwadkar, . A. R., Chenmarathy, . B. B. & Dharwadkar, . K. A. (2017) Cardioprotective function of progesterone: A new perspective. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 136-142. doi:10.5455/njppp.2017.7.0927404102016

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