E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats

Umesh Devappa Suranagi, Chetan Suresh Bhangale, Bhupinder Solanki, Ritika Bakshi, Ankit Arora.

Abstract
Background: Diabetes mellitus is associated with cognitive, neurophysiological, and structural changes in the central nervous system.

Aim and Objective: The aim of the study was to evaluate the effect of Ficus benghalensis on cognitive behavior and acetylcholinesterase levels in brain of diabetic rats, and to compare with Piracetam and Glimepiride.

Material and Methods: Wistar rats of either sex weighing 150200 g were randomized into ten groups of ten each (five groups of diabetic rats and five groups of non-diabetic rats) where one group of diabetic and one group of non-diabetic rats each received F. benghalensis dose I (50 mg/kg), F. benghalensis dose II (100 mg/kg), Piracetam (200 mg/kg) and Glimepiride (0.5 mg/kg), and one group of diabetic rats and one group of non-diabetic rats served as the control group. The blood glucose levels were assessed at 0 and 30th days. The assessment of acquisition phase of each cognitive behavior test was done on 0, 14th, and 29th days, whereas retention phase was assessed on 1st, 15th, and 30th days.

Results: In comparison with diabetic control group, F. benghalensis at both doses showed significant decrease in blood glucose levels as well as acquisition and retention of Transfer Latency in elevated plus maze on 29th and 30th days, respectively. Further, both doses exhibited significant increase in retention of step-down latency (SDL) on 30th in continuous avoidance apparatus, but only dose II showed significant increase in acquisition of SDL on 29th day. Similarly, significant increase in retention of Quadrant-time in Morris Water Maze was also observed with both doses of F. benghalensis and other groups compared to controls on 30th day. However, significant decrease in brain AChE level, was observed with only F. benghalensis dose II.

Conclusion: Overall, the positive effects of F. benghalensis on cognition were comparable to other two groups, namely, Piracetam and Glimepiride. Hence, it can be concluded that F. benghalensis might be effective in alleviating the behavioral and biochemical changes in diabetes mellitus.

Key words: Ficus benghalensis; Cognition; Piracetam; Diabetes Mellitus; Acetylcholinesterase


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Umesh Devappa Suranagi
Articles by Chetan Suresh Bhangale
Articles by Bhupinder Solanki
Articles by Ritika Bakshi
Articles by Ankit Arora
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Suranagi UD, Bhangale CS, Solanki B, Bakshi R, Arora A. An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. doi:10.5455/njppp.2022.12.08299202101092021


Web Style

Suranagi UD, Bhangale CS, Solanki B, Bakshi R, Arora A. An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. http://www.njppp.com/?mno=113550 [Access: October 01, 2021]. doi:10.5455/njppp.2022.12.08299202101092021


AMA (American Medical Association) Style

Suranagi UD, Bhangale CS, Solanki B, Bakshi R, Arora A. An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. doi:10.5455/njppp.2022.12.08299202101092021



Vancouver/ICMJE Style

Suranagi UD, Bhangale CS, Solanki B, Bakshi R, Arora A. An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. doi:10.5455/njppp.2022.12.08299202101092021



Harvard Style

Suranagi, U. D., Bhangale, . C. S., Solanki, . B., Bakshi, . R. & Arora, . A. (2022) An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. doi:10.5455/njppp.2022.12.08299202101092021



Turabian Style

Suranagi, Umesh Devappa, Chetan Suresh Bhangale, Bhupinder Solanki, Ritika Bakshi, and Ankit Arora. 2022. An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. doi:10.5455/njppp.2022.12.08299202101092021



Chicago Style

Suranagi, Umesh Devappa, Chetan Suresh Bhangale, Bhupinder Solanki, Ritika Bakshi, and Ankit Arora. "An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats." doi:10.5455/njppp.2022.12.08299202101092021



MLA (The Modern Language Association) Style

Suranagi, Umesh Devappa, Chetan Suresh Bhangale, Bhupinder Solanki, Ritika Bakshi, and Ankit Arora. "An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats." doi:10.5455/njppp.2022.12.08299202101092021



APA (American Psychological Association) Style

Suranagi, U. D., Bhangale, . C. S., Solanki, . B., Bakshi, . R. & Arora, . A. (2022) An open-label, randomized study to unfold the potential of Ficus benghalensis in modulation of cognitive impairment using diabetic (Streptozotocin induced) rats. doi:10.5455/njppp.2022.12.08299202101092021