E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood

Narendar Koyagura, Baswaraj Munge, Prasanna Vedula.

Abstract
Background: Conventionally, Ayurvedic herbs are being used to treat various diseases. These medicinal compounds have to be evaluated for their safety and presence of therapeutic compounds for the clinical application.

Aims and Objectives: The present study was designed to obtain the scientific knowledge on the safety profile as well as to assess the presence of pharmacologically active principles in the Pterocarpus marsupium heartwood.

Materials and methods: The aqueous extract of P. marsupium heartwood was subjected to an acute toxicity in albino rats. The animals were divided into four groups (n = 6) and fed with graded doses (1000, 2000, and 5000 mg/kg p.o.) of plant extract, respectively, whereas control group had received 2 ml distilled water orally. Animals were continuously observed for the toxicological symptoms for 2 h and intermittently for 48 h and latter once in a day for 14 days. The body weight of the animals was recorded. In addition, the qualitative phytochemical investigations were conducted to identify the presence of active principles.

Results: The animals fed with aqueous extract of P. marsupium heartwood did not exhibit any toxic symptoms and the mortality. However, there was a significant (P < 0.05) dose-dependent change in the weight gain observed in comparison to the control group. The median lethal dose (LD50) of the plant extract was considered as >5000 mg/kg. Furthermore, the phytochemical investigations of the plant extract showed the presence of carbohydrates, flavonoids, triterpenoids, saponins, tannins and phenols.

Conclusion: The aqueous extract of P. marsupium heartwood was found to be safe and well tolerated even at a large dose of 5000 mg/kg. Furthermore, the plant extract found to possess pharmacologically active principles having wide pharmacological spectrum. Hence, it can be preferred in various therapeutic conditions.

Key words: Acute Toxicity; Pterocarpus marsupium; Median Lethal Dose; Phytochemicals; Aqueous Extract


 
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How to Cite this Article
Pubmed Style

Koyagura N, Munge B, Vedula P. Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 707-711. doi:10.5455/njppp.2022.12.11400202107112021


Web Style

Koyagura N, Munge B, Vedula P. Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. https://www.njppp.com/?mno=137399 [Access: May 02, 2022]. doi:10.5455/njppp.2022.12.11400202107112021


AMA (American Medical Association) Style

Koyagura N, Munge B, Vedula P. Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 707-711. doi:10.5455/njppp.2022.12.11400202107112021



Vancouver/ICMJE Style

Koyagura N, Munge B, Vedula P. Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. Natl J Physiol Pharm Pharmacol. (2022), [cited May 02, 2022]; 12(5): 707-711. doi:10.5455/njppp.2022.12.11400202107112021



Harvard Style

Koyagura, N., Munge, . B. & Vedula, . P. (2022) Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. Natl J Physiol Pharm Pharmacol, 12 (5), 707-711. doi:10.5455/njppp.2022.12.11400202107112021



Turabian Style

Koyagura, Narendar, Baswaraj Munge, and Prasanna Vedula. 2022. Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 707-711. doi:10.5455/njppp.2022.12.11400202107112021



Chicago Style

Koyagura, Narendar, Baswaraj Munge, and Prasanna Vedula. "Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 707-711. doi:10.5455/njppp.2022.12.11400202107112021



MLA (The Modern Language Association) Style

Koyagura, Narendar, Baswaraj Munge, and Prasanna Vedula. "Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood." National Journal of Physiology, Pharmacy and Pharmacology 12.5 (2022), 707-711. Print. doi:10.5455/njppp.2022.12.11400202107112021



APA (American Psychological Association) Style

Koyagura, N., Munge, . B. & Vedula, . P. (2022) Acute toxicity study and phytochemical screening of Pterocarpus marsupium heartwood. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 707-711. doi:10.5455/njppp.2022.12.11400202107112021