Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy

C Vikram Deo; Munender Mamidi

doi:10.5455/njppp.2022.12.01005202206012022

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Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1193-1196

doi: 10.5455/njppp.2022.12.01005202206012022

Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy

C Vikram Deo, Munender Mamidi.

Abstract
Background: Endotracheal intubation and laryngoscopy are harmful stimulus, which can trigger unwanted cardiovascular conditions such as hypertension, dysrhythmia, and tachycardia. Various drugs have been used to attenuate the cardiovascular response. Drugs such as clonidine and Gabapentin are in extensive usage to stabilize the hemodynamic responses.

Aim and Objectives: The aim of the study was to assess the efficacy of 600 mg oral Gabapentin and 300 mcg oral clonidine in attenuating pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy.

Materials and Methods: This prospective randomized study consists of 100 cases between the age group 21 and 65 years posted for elective surgery under general anesthesia. The study cases were randomly divided into two groups. Group 1 (n = 50) administered with 600 mg oral Gabapentin and Group 2 (n = 50) administered with 300 mcg oral clonidine. The baseline and pre-operative hemodynamic parameters and levels of sedation score and anxiety scores were recorded.

Results: The total duration of intubation was 26.53 min in Group 1 and 26.86 min in Group 2. The systolic blood pressure, diastolic blood pressure, mean heart rate, mean arterial pressure, sedation score, and anxiety score were comparable between the two study groups and the mean difference between the two study groups was statistically significant (P < 0.05).

Conclusion: Both study drugs had similar significant anxiolysis and sedation scores. However, 300 μg oral clonidine has better hemodynamic stability to laryngoscopy and intubation than 600 mg oral gabapentin.

Key words: 600 mg Oral Gabapentin; 300 mcg Oral Clonidine; Hemodynamic Variables; Sedation Score; Anxiety Score

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Pubmed Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022

Web Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. https://www.njppp.com/?mno=140435 [Access: October 02, 2022]. doi:10.5455/njppp.2022.12.01005202206012022

AMA (American Medical Association) Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022

Vancouver/ICMJE Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol. (2022), [cited October 02, 2022]; 12(8): 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022

Harvard Style

Deo, C. V. & Mamidi, . M. (2022) Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol, 12 (8), 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022

Turabian Style

Deo, C Vikram, and Munender Mamidi. 2022. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022

Chicago Style

Deo, C Vikram, and Munender Mamidi. "Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022

MLA (The Modern Language Association) Style

Deo, C Vikram, and Munender Mamidi. "Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy." National Journal of Physiology, Pharmacy and Pharmacology 12.8 (2022), 1193-1196. Print. doi:10.5455/njppp.2022.12.01005202206012022

APA (American Psychological Association) Style

Deo, C. V. & Mamidi, . M. (2022) Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1193-1196. doi:10.5455/njppp.2022.12.01005202206012022



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