Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy

C Vikram Deo; Munender Mamidi

doi:10.5455/njppp.2022.12.01005202206012022

2022, Vol: 12, Issue: 5

12/5Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Natl J Physiol Pharm Pharmacol. 2022; 12(8):

doi: 10.5455/njppp.2022.12.01005202206012022

Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy

C Vikram Deo, Munender Mamidi.

Abstract
Background: Endotracheal intubation and laryngoscopy are harmful stimulus, which can trigger unwanted cardiovascular conditions such as hypertension, dysrhythmia, and tachycardia. Various drugs have been used to attenuate the cardiovascular response. Drugs such as clonidine and Gabapentin are in extensive usage to stabilize the hemodynamic responses.

Aim and Objectives: The aim of the study was to assess the efficacy of 600 mg oral Gabapentin and 300 mcg oral clonidine in attenuating pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy.

Materials and Methods: This prospective randomized study consists of 100 cases between the age group 21 and 65 years posted for elective surgery under general anesthesia. The study cases were randomly divided into two groups. Group 1 (n = 50) administered with 600 mg oral Gabapentin and Group 2 (n = 50) administered with 300 mcg oral clonidine. The baseline and pre-operative hemodynamic parameters and levels of sedation score and anxiety scores were recorded.

Results: The total duration of intubation was 26.53 min in Group 1 and 26.86 min in Group 2. The systolic blood pressure, diastolic blood pressure, mean heart rate, mean arterial pressure, sedation score, and anxiety score were comparable between the two study groups and the mean difference between the two study groups was statistically significant (P < 0.05).

Conclusion: Both study drugs had similar significant anxiolysis and sedation scores. However, 300 μg oral clonidine has better hemodynamic stability to laryngoscopy and intubation than 600 mg oral gabapentin.

Key words: 600 mg Oral Gabapentin; 300 mcg Oral Clonidine; Hemodynamic Variables; Sedation Score; Anxiety Score

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by C Vikram Deo Articles by Munender Mamidi
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol. Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022

Web Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. https://www.njppp.com/?mno=140435 [Access: May 02, 2022]. doi:10.5455/njppp.2022.12.01005202206012022

AMA (American Medical Association) Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol. Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022

Vancouver/ICMJE Style

Deo CV, Mamidi M. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol, [cited May 02, 2022]; Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022

Harvard Style

Deo, C. V. & Mamidi, . M. (2022) Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. Natl J Physiol Pharm Pharmacol, Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022

Turabian Style

Deo, C Vikram, and Munender Mamidi. 2022. Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022

Chicago Style

Deo, C Vikram, and Munender Mamidi. "Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy." National Journal of Physiology, Pharmacy and Pharmacology Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Deo, C. V. & Mamidi, . M. (2022) Comparative efficacy of 600 mg oral gabapentin and 300 mcg oral clonidine in attenuation of pre-operative anxiolysis and hemodynamic response to endotracheal intubation and laryngoscopy. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 13 Jan, 2022. doi:10.5455/njppp.2022.12.01005202206012022



Copyright � 2022 National Journal of Physiology, Pharmacy and Pharmacology All Rights Reserved. Subject to change without notice from or liability to National Journal of Physiology, Pharmacy and Pharmacology. For best results, please use Internet Explorer or Google Chrome	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272

Contact Information

How to cite this article