Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center

Akhil Gupta; Ranjan Bhatnagar; Manaswi Chaubey; Sanjay Yadav; Tamanna Singh; Akhilendra Choudhary

doi:10.5455/njppp.2023.13.03152202322062023

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06 / 07 / 2023

Natl J Physiol Pharm Pharmacol. 2024; 14(1): 170-174

doi: 10.5455/njppp.2023.13.03152202322062023

Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center

Akhil Gupta, Ranjan Bhatnagar, Manaswi Chaubey, Sanjay Yadav, Tamanna Singh, Akhilendra Choudhary.

Abstract
Background: Spondyloarthritis (SpA) is the disease of young population. Low bone mineral density (BMD) has been well documented in patients of ankylosing spondylitis but less studied in patients of SpA which includes reactive, enteropathic, psoriatic, and undifferentiated SpA.

Aims and Objectives: This study was done to evaluate the BMD in patients of SpA and its correlation with disease activity and inflammatory markers.

Materials and Methods: This was a cross-sectional case–control study. Thirty-five newly diagnosed SpA patients and equal number of age and sex matched healthy controls were included. A detailed history, examination, and dual-energy X-ray absorptiometry scan of lumber spine and femur neck was done.

Results: The mean age in our cases and control groups were 26.60 ± 6.63 years and 27.63 ± 4.10 years, respectively. The duration of illness was 2.3 ± 1.3 years. 71.4% patients were male and 28.6% were female. The mean C-reactive protein (CRP) values at the time of diagnosis was 7.56 ± 3.4 mg/L. The mean bath ankylosing spondylitis disease activity index (BASDAI) values in patients were 3.17 ± 2.9. BMD correlated with baseline BASDAI and male sex (P < 0.005) among cases and controls. However, we found no relationship between reduced BMD with the pattern of joint involvement, HLA B27 positivity, CRP levels, and duration of onset of symptoms.

Conclusion: The result of this study shows that patients of SpA with high BASDAI score at a very early age are predisposed to low BMD.

Key words: Spondyloarthritis; Bone Mineral Density; DEXA Scan; C-reactive Protein; Osteopenia; Osteoporosis

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How to Cite this Article

Pubmed Style

Gupta A, Bhatnagar R, Chaubey M, Yadav S, Singh T, Choudhary A. Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. Natl J Physiol Pharm Pharmacol. 2024; 14(1): 170-174. doi:10.5455/njppp.2023.13.03152202322062023

Web Style

Gupta A, Bhatnagar R, Chaubey M, Yadav S, Singh T, Choudhary A. Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. https://www.njppp.com/?mno=147207 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.03152202322062023

AMA (American Medical Association) Style

Gupta A, Bhatnagar R, Chaubey M, Yadav S, Singh T, Choudhary A. Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. Natl J Physiol Pharm Pharmacol. 2024; 14(1): 170-174. doi:10.5455/njppp.2023.13.03152202322062023

Vancouver/ICMJE Style

Gupta A, Bhatnagar R, Chaubey M, Yadav S, Singh T, Choudhary A. Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. Natl J Physiol Pharm Pharmacol. (2024), [cited March 14, 2024]; 14(1): 170-174. doi:10.5455/njppp.2023.13.03152202322062023

Harvard Style

Gupta, A., Bhatnagar, . R., Chaubey, . M., Yadav, . S., Singh, . T. & Choudhary, . A. (2024) Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. Natl J Physiol Pharm Pharmacol, 14 (1), 170-174. doi:10.5455/njppp.2023.13.03152202322062023

Turabian Style

Gupta, Akhil, Ranjan Bhatnagar, Manaswi Chaubey, Sanjay Yadav, Tamanna Singh, and Akhilendra Choudhary. 2024. Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. National Journal of Physiology, Pharmacy and Pharmacology, 14 (1), 170-174. doi:10.5455/njppp.2023.13.03152202322062023

Chicago Style

Gupta, Akhil, Ranjan Bhatnagar, Manaswi Chaubey, Sanjay Yadav, Tamanna Singh, and Akhilendra Choudhary. "Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 170-174. doi:10.5455/njppp.2023.13.03152202322062023

MLA (The Modern Language Association) Style

Gupta, Akhil, Ranjan Bhatnagar, Manaswi Chaubey, Sanjay Yadav, Tamanna Singh, and Akhilendra Choudhary. "Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center." National Journal of Physiology, Pharmacy and Pharmacology 14.1 (2024), 170-174. Print. doi:10.5455/njppp.2023.13.03152202322062023

APA (American Psychological Association) Style

Gupta, A., Bhatnagar, . R., Chaubey, . M., Yadav, . S., Singh, . T. & Choudhary, . A. (2024) Evaluation of bone mineral density in patients of spondyloarthritis in a tertiary care center. National Journal of Physiology, Pharmacy and Pharmacology, 14 (1), 170-174. doi:10.5455/njppp.2023.13.03152202322062023

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