Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia

Veena Mathur; Rajendrapal Singh Rathore; Deepak Kumar Garg; Surendra Kumar Sethi; Arvind Khare; Meera Kumari

doi:10.5455/njppp.2023.13.04197202312062023

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Natl J Physiol Pharm Pharmacol. 2024; 14(1): 153-159

doi: 10.5455/njppp.2023.13.04197202312062023

Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia

Veena Mathur, Rajendrapal Singh Rathore, Deepak Kumar Garg, Surendra Kumar Sethi, Arvind Khare, Meera Kumari.

Abstract
Background: Laryngoscopy and endotracheal intubation, pneumoperitoneum, and tracheal extubation may lead to adverse hemodynamic responses during laparoscopic surgeries under general anesthesia.

Aims and Objectives: The present study aimed to compare the effectiveness of oral pregabalin and oral clonidine on perioperative hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia.

Materials and Methods: Sixty patients aged 18–60 years of the American Society of Anesthesiologists Physical Status I or II were randomly divided into two groups. Group C (n = 30) received oral clonidine 200 μg and Group P (n = 30) received oral pregabalin 150 mg as a premedication undergoing laparoscopic cholecystectomy under general anesthesia. The hemodynamic variables, i.e., heart rate, systolic, diastolic, mean arterial blood pressure, along with the duration of post-operative analgesia, level of sedation, and any adverse effects were noted. The data to be analyzed were entered into Microsoft Excel and statistical analysis was done using the Statistical Package of the Social Sciences version 16 software.

Results: The attenuation of hemodynamic response following laryngoscopy and endotracheal intubation, pneumoperitoneum, and extubation was significantly better in clonidine group. Group P (655.8 ± 282.0 min) (P < 0.05) had significantly prolonged duration of post-operative analgesia as compared to Group C (295.8 ± 54.6 min) (P < 0.05). Group P showed significantly higher sedation scores before induction (P < 0.05). Mean total rescue analgesic consumption was significantly lower in Group P (P < 0.05). Side effect profile was comparable in two groups (P > 0.05).

Conclusion: Clonidine and pregabalin both were found to be effective in attenuation of perioperative hemodynamic response. However, pregabalin prolonged the duration of analgesia along with lesser rescue analgesic consumption, acceptable sedation, and no or minimal side effects.

Key words: Pregabalin; Clonidine; Laparoscopic Cholecystectomy; Hemodynamic Response; Post-operative Analgesia; Sedation

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How to Cite this Article

Pubmed Style

Mathur V, Rathore RS, Garg DK, Sethi SK, Khare A, Kumari M. Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. Natl J Physiol Pharm Pharmacol. 2024; 14(1): 153-159. doi:10.5455/njppp.2023.13.04197202312062023

Web Style

Mathur V, Rathore RS, Garg DK, Sethi SK, Khare A, Kumari M. Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. https://www.njppp.com/?mno=149440 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.04197202312062023

AMA (American Medical Association) Style

Mathur V, Rathore RS, Garg DK, Sethi SK, Khare A, Kumari M. Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. Natl J Physiol Pharm Pharmacol. 2024; 14(1): 153-159. doi:10.5455/njppp.2023.13.04197202312062023

Vancouver/ICMJE Style

Mathur V, Rathore RS, Garg DK, Sethi SK, Khare A, Kumari M. Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. Natl J Physiol Pharm Pharmacol. (2024), [cited March 14, 2024]; 14(1): 153-159. doi:10.5455/njppp.2023.13.04197202312062023

Harvard Style

Mathur, V., Rathore, . R. S., Garg, . D. K., Sethi, . S. K., Khare, . A. & Kumari, . M. (2024) Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. Natl J Physiol Pharm Pharmacol, 14 (1), 153-159. doi:10.5455/njppp.2023.13.04197202312062023

Turabian Style

Mathur, Veena, Rajendrapal Singh Rathore, Deepak Kumar Garg, Surendra Kumar Sethi, Arvind Khare, and Meera Kumari. 2024. Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. National Journal of Physiology, Pharmacy and Pharmacology, 14 (1), 153-159. doi:10.5455/njppp.2023.13.04197202312062023

Chicago Style

Mathur, Veena, Rajendrapal Singh Rathore, Deepak Kumar Garg, Surendra Kumar Sethi, Arvind Khare, and Meera Kumari. "Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 153-159. doi:10.5455/njppp.2023.13.04197202312062023

MLA (The Modern Language Association) Style

Mathur, Veena, Rajendrapal Singh Rathore, Deepak Kumar Garg, Surendra Kumar Sethi, Arvind Khare, and Meera Kumari. "Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia." National Journal of Physiology, Pharmacy and Pharmacology 14.1 (2024), 153-159. Print. doi:10.5455/njppp.2023.13.04197202312062023

APA (American Psychological Association) Style

Mathur, V., Rathore, . R. S., Garg, . D. K., Sethi, . S. K., Khare, . A. & Kumari, . M. (2024) Comparison of effectiveness of clonidine versus pregabalin as an oral premedication for hemodynamic response and post-operative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. National Journal of Physiology, Pharmacy and Pharmacology, 14 (1), 153-159. doi:10.5455/njppp.2023.13.04197202312062023

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