E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
10 / 11 / 2014

 


Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi.


Abstract
Background: Poloxamer 407 is used in parenteral formulations as solubilizing and wetting agent for traditional, low-molecular-weight organic drug molecules and as stabilizing agent for proteins and polypeptide drugs. It has very high promising value in the medicine field, but has held responsible for changes in the lipid parameters. Thus, effect of poloxamer 407 on the rabbit’s serum very low density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels was studied after being injected intravenously.

Aims & Objective: To study the effect of poloxamer 407 on rabbit’s serum VLDL, LDL, and HDL levels following intravenous injection.

Materials and Methods: Pretreatment, baseline readings were recorded. Rabbits were injected with 5.5, 27.5, and 137.5 mg/kg of poloxamer 407, and the effects on blood chemistry were assessed on the 2nd, 4th, and 7th day. The results of the study were expressed as mean ± SEM, and data were analyzed using one-way analysis of variance test. Values with P < 0.05 were considered as significant.


Results: The highest dose of poloxamer 407 (137.5 mg/kg) significantly increased serum VLDL and decreased HDL level in rabbits, with the maximum increase observed on the 2nd day after injection. All the doses given did not alter the serum LDL level. The lower doses of poloxamer 407 did not alter serum VLDL, LDL, and HDL levels.


Conclusion: Our results showed that poloxamer 407 in higher doses significantly increased serum VLDL and decreased HDL levels but in lower doses did not show any adverse effect on the lipid biochemistry. But we recommend further studies to know the effect of this poloxamer on chronic use and through different route of administration.

Key words: Poloxamer 407; Very Low Density Lipoprotein; Low-Density Lipoprotein; High-Density Lipoprotein; Rabbit


 
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How to Cite this Article
Pubmed Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. Natl J Physiol Pharm Pharmacol. 2014; 4(3): 221-224. doi:10.5455/njppp.2014.4.040620141


Web Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. https://www.njppp.com/?mno=160666 [Access: March 14, 2024]. doi:10.5455/njppp.2014.4.040620141


AMA (American Medical Association) Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. Natl J Physiol Pharm Pharmacol. 2014; 4(3): 221-224. doi:10.5455/njppp.2014.4.040620141



Vancouver/ICMJE Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. Natl J Physiol Pharm Pharmacol. (2014), [cited March 14, 2024]; 4(3): 221-224. doi:10.5455/njppp.2014.4.040620141



Harvard Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi (2014) Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. Natl J Physiol Pharm Pharmacol, 4 (3), 221-224. doi:10.5455/njppp.2014.4.040620141



Turabian Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. 2014. Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 4 (3), 221-224. doi:10.5455/njppp.2014.4.040620141



Chicago Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. "Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits." National Journal of Physiology, Pharmacy and Pharmacology 4 (2014), 221-224. doi:10.5455/njppp.2014.4.040620141



MLA (The Modern Language Association) Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi. "Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits." National Journal of Physiology, Pharmacy and Pharmacology 4.3 (2014), 221-224. Print. doi:10.5455/njppp.2014.4.040620141



APA (American Psychological Association) Style

Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi (2014) Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 4 (3), 221-224. doi:10.5455/njppp.2014.4.040620141