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A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar.

Cited by (6)

Abstract
Background: Derangement of gonadal functions has been reported in association with HIV infection, but data from Indian population are not sufficient.

Aims & Objective: To evaluate the effect of highly active antiretroviral therapy (HAART) on the gonadal dysfunction in male HIV patients.

Materials and Methods: A total of 45 male HIV-positive patients were included and divided in two groups on the basis of CD4 cell count. Patients in groups A and B had CD4 count ≤200 and >200 cell/μL, respectively. Baseline hormone level was measured before the start of HAART, and the patients were followed up for 6 months and the hormone levels were measured again.

Results: In group A (n = 29), six (20.69%) patients had testosterone level <200 ng/dL, among them four (66.67%) patients had low luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (secondary hypogonadism) levels. In group B (n = 16), none of the patients had low testosterone level whereas two (12.5%) and seven (43.8%) had low LH and FSH level, respectively. Overall of 45 patients, 6 (13.33%) had hypogonadism. Of these six patients, four (66.67%) were having secondary whereas two (33.33%) were primary hypogonadism. After 6 months, condition of five of these six (83.33%) patients improved on HAART.

Conclusion: This study showed the improvement in gonadal dysfunction in HIV patients on administration of HAART. Although the number of patients included in this study was small, but this pilot study provides a basis for further evaluation by a large longitudinal study to substantiate its findings.

Key words: Highly Active Antiretroviral Therapy (HAART); Human Immunodeficiency Virus (HIV); Endocrine Changes


 
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How to Cite this Article
Pubmed Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35. doi:10.5455/njppp.2015.5.120720142


Web Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. http://www.njppp.com/?mno=160716 [Access: September 01, 2020]. doi:10.5455/njppp.2015.5.120720142


AMA (American Medical Association) Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35. doi:10.5455/njppp.2015.5.120720142



Vancouver/ICMJE Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. Natl J Physiol Pharm Pharmacol. (2015), [cited September 01, 2020]; 5(1): 33-35. doi:10.5455/njppp.2015.5.120720142



Harvard Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar (2015) A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. Natl J Physiol Pharm Pharmacol, 5 (1), 33-35. doi:10.5455/njppp.2015.5.120720142



Turabian Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. 2015. A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 33-35. doi:10.5455/njppp.2015.5.120720142



Chicago Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. "A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 33-35. doi:10.5455/njppp.2015.5.120720142



MLA (The Modern Language Association) Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar. "A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients." National Journal of Physiology, Pharmacy and Pharmacology 5.1 (2015), 33-35. Print. doi:10.5455/njppp.2015.5.120720142



APA (American Psychological Association) Style

Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar (2015) A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 33-35. doi:10.5455/njppp.2015.5.120720142