E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
26 / 09 / 2023

 


To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle

Tamoghna Maiti, Sonai Mandal, Anuran Bhadury, Olivia Mukhopadhyay.


Abstract
Background: Momordica charantia, Gymnema sylvestre, and Piper betle are developing as optional therapy in type 2 diabetes. Animal studies are helping to reveal its anti-diabetic properties. However, clinical studies in human subjects are few.

Aims and Objectives: To know the effect of M. charantia on fasting glycemic control in rabbits.

Materials and Methods: Blood samples from overnight fasting diabetic rabbits were collected. The drug and vehicle at the indicated dosages were then administered orally to the respective groups using a pediatric nasogastric tube followed by 2 mL of distilled water through the same tube. Subsequent blood samples were taken 2, 4, and 8 h after drug administration, and plasma glucose was estimated for each sample.

Results: The standard drug, glyburide, significantly reduces hyperglycemia over a period of 2, 4, and 8 h, with maximum effect achieved after 4 h. Therefore, the choice of a diabetic rabbit animal model is authentic and appropriate.

Conclusion: These three herbal extracts were more or less equivalent in reducing fasting blood glucose compared to glyburide in a rabbit model.

Key words: Animal Model; Diabetes Mellitus; Gymnema sylvestre; Momordica charantia


 
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How to Cite this Article
Pubmed Style

Maiti T, Mandal S, Bhadury A, Mukhopadhyay O. To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. Natl J Physiol Pharm Pharmacol. Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023


Web Style

Maiti T, Mandal S, Bhadury A, Mukhopadhyay O. To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. https://www.njppp.com/?mno=168691 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.09433202313092023


AMA (American Medical Association) Style

Maiti T, Mandal S, Bhadury A, Mukhopadhyay O. To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. Natl J Physiol Pharm Pharmacol. Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023



Vancouver/ICMJE Style

Maiti T, Mandal S, Bhadury A, Mukhopadhyay O. To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. Natl J Physiol Pharm Pharmacol, [cited March 14, 2024]; Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023



Harvard Style

Maiti, T., Mandal, . S., Bhadury, . A. & Mukhopadhyay, . O. (2024) To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. Natl J Physiol Pharm Pharmacol, Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023



Turabian Style

Maiti, Tamoghna, Sonai Mandal, Anuran Bhadury, and Olivia Mukhopadhyay. 2024. To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023



Chicago Style

Maiti, Tamoghna, Sonai Mandal, Anuran Bhadury, and Olivia Mukhopadhyay. "To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle." National Journal of Physiology, Pharmacy and Pharmacology Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023



MLA (The Modern Language Association) Style

Maiti, Tamoghna, Sonai Mandal, Anuran Bhadury, and Olivia Mukhopadhyay. "To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle." National Journal of Physiology, Pharmacy and Pharmacology Online First: 26 Sep, 2023. Web. 14 Mar 2024 doi:10.5455/njppp.2023.13.09433202313092023



APA (American Psychological Association) Style

Maiti, T., Mandal, . S., Bhadury, . A. & Mukhopadhyay, . O. (2024) To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 26 Sep, 2023. doi:10.5455/njppp.2023.13.09433202313092023