Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units

Manu S Menon; Simbita Marwah; Mihir Mehta; Arya D Dipak

doi:10.5455/njppp.2015.5.2011201410

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Natl J Physiol Pharm Pharmacol. 2015; 5(3): 166-169

doi: 10.5455/njppp.2015.5.2011201410

Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak.

Cited by (3)

Abstract
Background: It is very crucial to recognize infection in immunocompromised patients. The purpose of this study was to explore the diagnostic accuracy of C-reactive protein (CRP) in critically ill immunocompromised patients with sepsis.<Q: Since the same is appearing under Aim and Objective already, please consider deleting the sentence The purpose ofwith sepsis and providing some different information.>

Aims and Objective: To find out the diagnostic utility of CRP in immunocompromised patients with sepsis.

Materials and Methods: This was a cross-sectional study, which included immunocompromised patients with suspected sepsis. Patients were classified into two diagnostic groups: those with nonbacterial sepsis and those with bacterial sepsis, and the values of CRP were estimated.

Results: Of 94 patients (63 men and 31 women) with a median age of 56 years (95% CI 53.959.3), 74 (78.5%) had immunosuppression with nonbacterial sepsis and 20 (21.4%) had immunosuppression with bacterial sepsis. CRP concentrations were higher in the group with bacterial sepsis [30.94 ng/ml (95% CI 25.1336.74)] than those with nonbacterial sepsis [7.46 ng/ml (95% CI 7.057.87), P < 0.0001]. CRP concentrations that were >6 mg/L had 93.33% sensitivity but only 63.20% specificity for diagnosing sepsis. The accuracy of diagnosis was 87.23%. The area under the receiver-operating characteristic curve was 0.82 (0.720.92).

Conclusion: Despite limited specificity in critically ill immunocompromised patients, CRP concentrations may help to rule out bacterial infection.

Key words: C-reactive protein; Immune deficiency; Bacterial sepsis; Non-bacterial sepsis

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REFERENCES

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-54. [DOI via Crossref] [Pubmed]

2. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-10. [DOI via Crossref] [Pubmed]

3. Hansson LO, Lindquist L. C-reactive protein: its role in the diagnosis and follow-up of infectious diseases. Curr Opin Infect Dis. 1997;10:196-201. [DOI via Crossref]

4. Lehrnbecher T, Venzon D, de Haas M, Chanock SJ, Kuehl J. Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III, and mannose-binding protein in febrile children with cancer and neutropenia. Clin Infect Dis. 1999;29:414-9. [DOI via Crossref] [Pubmed]

5. Katz JA, Mustafa MM, Bash RO, Cash JV, Buchanan GR. Value of C-reactive protein determination in the initial diagnostic evaluation of the febrile, neutropenic child with cancer. Pediatr Infect Dis J. 1992;11:708-12. [DOI via Crossref] [Pubmed]

6. Engel A, Mack E, Kern P, Kern WV. An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteraemia and complicated infection in neutropenic cancer patients. Infection. 1998;26:213-21. [DOI via Crossref] [Pubmed]

7. Farag NA, Taema KM, Abdel-Latiff E, Hamed G. Differentiating sepsis from non-infective systemic inflammatory response syndrome: comparison between C-reactive protein and Leptin. Egypt J Crit Care Med. 2013;1(3):111-118. [DOI via Crossref]

8. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348(2):138-50. [DOI via Crossref] [Pubmed]

9. Gullo A, Bianco N, Berlot G. Management of severe sepsis and septic shock: challenges and recommendations. Crit Care Clin. 2006; 22(3):489-501. [DOI via Crossref] [Pubmed]

10. Zambon M, Ceola M, Almeida-de-Castro R, Gullo A, Vincent JL. Implementation of the Surviving Sepsis Campaign guidelines for severe sepsis and septic shock: we could go faster. J Crit Care. 2008;23(4):455-60. [DOI via Crossref] [Pubmed]

11. Chan Y, Liao H, Tsay P, Chang S, Chen J, Liaw S. C-reactive protein as n indicator of bacterial infection of adult patients in the emergency department. Chang Gung Med J. 2002;25(7):437-44. [Pubmed]

12. Ugarte H, Silva E, Mercan D, De Mendonca A, Vincent JL. Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med. 1999;27:498-504. [DOI via Crossref] [Pubmed]

13. Suprin E, Camus C, Gacouin A, Le Tulzo Y, Lavoue S, Feuillu A, et al. Procalcitonin: a valuable indicator of infection in a medical ICU? Intensive Care Med. 2000;26:1232-8. [DOI via Crossref] [Pubmed]

14. Muller B, Becker KL, Schachinger H, Rickenbacher PR, Huber PR, Zimmerli W, et al. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med. 2000; 28:977-83. [DOI via Crossref] [Pubmed]

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How to Cite this Article

Pubmed Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 166-169. doi:10.5455/njppp.2015.5.2011201410

Web Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. https://www.njppp.com/?mno=173258 [Access: June 01, 2022]. doi:10.5455/njppp.2015.5.2011201410

AMA (American Medical Association) Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 166-169. doi:10.5455/njppp.2015.5.2011201410

Vancouver/ICMJE Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol. (2015), [cited June 01, 2022]; 5(3): 166-169. doi:10.5455/njppp.2015.5.2011201410

Harvard Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak (2015) Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol, 5 (3), 166-169. doi:10.5455/njppp.2015.5.2011201410

Turabian Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. 2015. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 166-169. doi:10.5455/njppp.2015.5.2011201410

Chicago Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. "Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 166-169. doi:10.5455/njppp.2015.5.2011201410

MLA (The Modern Language Association) Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak. "Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 166-169. Print. doi:10.5455/njppp.2015.5.2011201410

APA (American Psychological Association) Style

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak (2015) Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 166-169. doi:10.5455/njppp.2015.5.2011201410



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