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Original Research

Online Publishing Date:
02 / 07 / 2015

 


Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta.


Abstract
Background: The treatment of dry eyes has traditionally involved hydrating and lubricating the ocular surface, which include usage of artificial tear drops [carboxymethyl cellulose (CMC)]. Corticosteroids possess potential anti-inflammatory properties, thereby used in controlling inflammation in many organs. FDA has approved the prescription of topical corticosteroids for corticosteroid-responsive inflammatory conditions such as dry eye diseases.

Aims and Objective: To compare the effect of topical CMC alone or in combination with topical corticosteroid for the treatment of dry eye in a tertiary-care teaching hospital.

Materials and Methods: A total of 60 patients diagnosed with dry eye were enrolled for a study period of 1 year. Patients (n = 60) were stabilized on CMC for 2 weeks and there then divided into two groups: group I (n = 30), CMC; group II (n = 30), CMC + corticosteroid. The patients were followed up for 12 weeks. Diagnostic tests included Schirmer’s test and tear breakup time (TBUT) test. Quality of life was assessed by Ocular Surface Disease Index (OSDI). Analysis was done by t test; p <0.05 was considered significant.

Results: Schirmer’s values in groups I and II at 0 and 12 weeks were 7.8 ± 0.81 and 15.4 ± 0.62 (p < 0.0001) and 7.43 ± 0.42 and 17.53 ± 0.25 (p < 0.0001), respectively. TBUT values in groups I and II at 0 and 12 weeks were 4.93 ± 0.44 and 9.36 ± 0.35 (p < 0.0001) and 4.5 ± 0.38 and 10.43 ± 0.22 (p < 0.0001), respectively. OSDI score in groups I and II at 0 and 12 weeks were 87.64 ± 1.41 and 54.25 ± 1.09 (p < 0.0001) and 91.17 ± 1.13 and 53.55 ± 1.14 (p < 0.0001), respectively. At 12 weeks, intergroup comparison in Schirmer’s test (p < 0.05), TBUT test (p < 0.05), and OSDI score (p < 0.05) was done. Burning and stinging, photophobia, discharge, ocular infection, and increased intraocular pressure were among the common adverse effects seen.

Conclusion: Both groups showed significant improvement in Schirmer’s test, TBUT test, and OSDI score at the end of study. Intergroup comparison showed significant improvement in the group where corticosteroid was added. Adding corticosteroid ameliorated the symptoms rapidly but short-term use recommended because of adverse effects.

Key words: Dry Eye, Carboxymethyl Cellulose, Corticosteroid, Schirmer’s Test, Tear Breakup Time Test, Ocular Surface Disease Index


 
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How to Cite this Article
Pubmed Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 207-211. doi:10.5455/njppp.2015.5.1601201519

Web Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. https://www.njppp.com/?mno=177694 [Access: March 14, 2024]. doi:10.5455/njppp.2015.5.1601201519

AMA (American Medical Association) Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 207-211. doi:10.5455/njppp.2015.5.1601201519


Vancouver/ICMJE Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol. (2015), [cited March 14, 2024]; 5(3): 207-211. doi:10.5455/njppp.2015.5.1601201519


Harvard Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta (2015) Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol, 5 (3), 207-211. doi:10.5455/njppp.2015.5.1601201519


Turabian Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. 2015. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 207-211. doi:10.5455/njppp.2015.5.1601201519


Chicago Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. "Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 207-211. doi:10.5455/njppp.2015.5.1601201519


MLA (The Modern Language Association) Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta. "Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 207-211. Print. doi:10.5455/njppp.2015.5.1601201519


APA (American Psychological Association) Style

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta (2015) Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 207-211. doi:10.5455/njppp.2015.5.1601201519


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