E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata

Vetriselvan Subramaniyan, Anil Middha.

Cited by (1)

Abstract
Background: Chronic alcohol consumption is a known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The present experimental model was evaluated with medicinal plant Boswellia serrata and the results reflected potential beneficial and reducing risk factors for liver disease.

Aims and Objectives: To determine the hepatoprotective activity of aqueous extract of Boswellia serrata. Chronic ethanol consumption is a major risk factor in determining liver disease and other metabolic syndrome via multiple mechanisms, including the regulation of the lipid metabolism.

Materials and Methods: Male Wistar rats were divided into 6 groups (n = 6/group), and fed with a standard diet, ethanol, and ethanol supplemented with extracts for 6 weeks. The ethanol changes were determined via a serum enzyme profile of the liver. Liver toxicity was assessed in terms such as, serum indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, total proteins, albumin, globulin, albumin: globulin ratio, and liver weight.

Results: Oral administration of 250 and 500 mg/kg of AEBS offered a significant (P < 0.01) dose-dependent protection against ethanol-induced hepatotoxicity.

Conclusion: This study revealed that aqueous extract of Boswellia serrata in phytochemical constituents plays an active role against enzymes’ elevation and protection of liver.

Key words: Boswellia serrata; Ethanol; Serum Enzymes; Hepatotoxicity; Hepatoprotective


 
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How to Cite this Article
Pubmed Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106


Web Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. https://www.njppp.com/?mno=211692 [Access: June 02, 2022]. doi:10.5455/njppp.2016.6.24122015106


AMA (American Medical Association) Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106



Vancouver/ICMJE Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. (2016), [cited June 02, 2022]; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106



Harvard Style

Vetriselvan Subramaniyan, Anil Middha (2016) Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106



Turabian Style

Vetriselvan Subramaniyan, Anil Middha. 2016. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106



Chicago Style

Vetriselvan Subramaniyan, Anil Middha. "Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 170-174. doi:10.5455/njppp.2016.6.24122015106



MLA (The Modern Language Association) Style

Vetriselvan Subramaniyan, Anil Middha. "Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata." National Journal of Physiology, Pharmacy and Pharmacology 6.2 (2016), 170-174. Print. doi:10.5455/njppp.2016.6.24122015106



APA (American Psychological Association) Style

Vetriselvan Subramaniyan, Anil Middha (2016) Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106