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Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R.

Cited by (4)

Abstract
Background: Globally, diabetes mellitus has now emerged as a major public health problem, especially in India. Diabetic neuropathy may occur in nearly half of the patients with long-standing diabetes mellitus. In diabetes mellitus, the determinants of cardiac autonomic dysfunction were duration of diabetes, extent of glycemic control, age, and gender.

Aims and Objective: To study the various ECG abnormalities in type 2 diabetes mellitus patients when compared with control subjects.

Materials and Methods: The study was carried out as a hospital-based cross-sectional study among 50 diabetic patients and 50 age- and sex-matched control subjects. Resting ECG was recorded among study and control groups and compared. SPSS, version 20.0, was used for statistical analysis; unpaired t test was used to test the statistical difference in comparison of means, and a p value of <0.05 was considered statistically significant.

Result: The study results showed that certain ECG changes such as resting heart rate, RR interval, PR interval, QRS axis, and QTc interval significantly varied between study and control groups. Abnormal heart rate response to deep breathing and postural hypotension were observed at higher frequency among patients with diabetes mellitus.

Conclusion: Evaluation of various cardiovascular reflexes and ECG in type 2 diabetic patients may serve as a feasible technique to determine the presence of cardiac dysautonomia.

Key words: Diabetes Mellitus; Cardiac Autonomic Dysfunction; ECG Changes


 
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REFERENCES
1. IDF Diabetes Atlas 2013. Available at: http://www.idf.org/sites/default/files/EN_6E_Atlas_Full_0.pdf [accessed June 20, 2014].
2. Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J. Harrison’s Principles of Internal Medicine, 18 edn. New York: McGraw-Hill Professional, 2012.
3. Walker BR, Colledge NR, Ralston SH, Penman I. Davidson’s Principles and Practice of Medicine. Philadelphia, PA: Elsevier Health Sciences, 2013.
4. Stella P, Ellis D, Maser RE, Orchard TJ. Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes: incidence and predictors. J Diabetes Complications. 2000;14:1-6. [DOI via Crossref]   
5. Witte D, Tesfaye S, Chaturvedi N, Eaton SE, Kempler P, Fuller JH; EURODIAB Prospective Complications Study Group. Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus. Diabetologia. 2005;48:164-171. [DOI via Crossref]    [Pubmed]   
6. Ziegler D, Gries F, Muhlen H, Rathmann W, Spuler M, Lessmann F. Prevalence and clinical correlates of cardiovascular autonomic and peripheral diabetic neuropathy in patients attending diabetes centers. The Diacan Multicenter Study Group. Diab Metab. 1992;19:143-151.
7. Kahn JK, Sisson JC, Vinik AI. QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. J Clin Endocrinol Metab. 1987;64:751-754. [DOI via Crossref]    [Pubmed]   
8. Mustonen J, Uusitupa M, Mäntysaari M, Länsimies E, Pyorälä K, Laakso M. Changes in autonomic nervous function during the 4-year follow-up in middle-aged diabetic and nondiabetic subjects initially free of coronary heart disease. J Intern Med. 1997;241:231-239. [DOI via Crossref]   
9. Mathur C, Gupta D. QTc prolongation in diabetes mellitus—an indicator of cardiac autonomic neuropathy. J Indian Acad Clin Med. 2006;17:34.00.
10. Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham study. JAMA. 1979;241:2035-2038. [DOI via Crossref]   
11. Negrusz-Kawecka M, Moszczyńska-Stulin J, Zytkiewicz-Jaruga D, Salomon P. [Frequency of silent ischemic heart disease in patients with diabetes mellitus]. Pol Merkur Lekarski. 1997;3:53-56.
12. Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115:387-397. [DOI via Crossref]    [Pubmed]   
13. Domuschiev I. Cardiac autonomic neuropathy and its correlation with retinopathy in type 2 diabetics. Biotechnol Biotechnol Equip. 2005;19:180-183. [DOI via Crossref]   

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How to Cite this Article
Pubmed Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 178-181. doi:10.5455/njppp.2016.6.27122015107


Web Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. https://www.njppp.com/?mno=211974 [Access: June 02, 2022]. doi:10.5455/njppp.2016.6.27122015107


AMA (American Medical Association) Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 178-181. doi:10.5455/njppp.2016.6.27122015107



Vancouver/ICMJE Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. Natl J Physiol Pharm Pharmacol. (2016), [cited June 02, 2022]; 6(3): 178-181. doi:10.5455/njppp.2016.6.27122015107



Harvard Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R (2016) Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. Natl J Physiol Pharm Pharmacol, 6 (3), 178-181. doi:10.5455/njppp.2016.6.27122015107



Turabian Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. 2016. Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 178-181. doi:10.5455/njppp.2016.6.27122015107



Chicago Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. "Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 178-181. doi:10.5455/njppp.2016.6.27122015107



MLA (The Modern Language Association) Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R. "Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 6.3 (2016), 178-181. Print. doi:10.5455/njppp.2016.6.27122015107



APA (American Psychological Association) Style

Vijay Prasad C, Darshan Savery M, Vishnu Prasad R (2016) Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus—a comparative cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 178-181. doi:10.5455/njppp.2016.6.27122015107