E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital

Sri Vidya BP, Nagabushan H.

Abstract
Background: Pregnancy care is one of the greatest challenges in medicine and it demands a special care in the use of drugs because of altered physiology. For the use of drugs during pregnancy immense precaution has to be taken because health of both mother and foetus may be affected.

Aims and Objectives: To study and evaluate the drug use pattern among inpatients of OBG Department in a tertiary care teaching hospital, to study and evaluate the pharmacological interventions in complicated pregnancies in obstetric ward in a tertiary care hospital, and to assess the World Health Organization (WHO) core prescription indicators.

Materials and Methods: Prospective observational study was carried out among inpatient of obstetric wards of tertiary care teaching hospital over a period of 3 months. All pregnant women diagnosed to have complications were included in the study. The data regarding demographic details, period of gestation, provisional diagnosis, and complete prescription were collected using specially designed proforma and were analyzed for drug use pattern, WHO core drug prescribing indicators and Food and Drug Administration (FDA) pregnancy drug risk category.

Result: Among 285 patients, 105 (37%) were primigravida and 180 (63%) were multigravida. Majority of them (82%) were in the age group of 20-30 years. Anemia is the most common condition complicating pregnancy, constituting 24% followed by oligohydramnios (13%), PIH (9%), hyperemesis gravidarum (7%) of overall complications, respectively. Haematinics and blood components (20%), antibiotics (13%) are the most commonly prescribed drugs followed by protein supplement (11%) and steroids (8%). As per FDA pregnancy drug category, category-B (41.17%) was most frequently prescribed followed by category-A and C each contributing to 29.41%. Percentage of drugs prescribed by generic name was 57% and from essential drug list it was 42%.

Conclusion: Haematinics, protein supplements, and antibiotics are the most commonly prescribed drugs. None of the drugs were from Category D and X. There was lesser number of drugs prescribed by generic name, which needs improvement.

Key words: Anemia; FDA Pregnancy Category; WHO Prescription Indicators


 
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REFERENCES
1. Joshi HM, Joshi JM, Patel KP, Shah KN, Patel VJ. Morbidity and drug utilization pattern among admitted pregnant anaemic women and to find out rationality of drug by using Indian guidelines. Int J Basic Clin Pharmacol. 2014;3:947–53. [DOI via Crossref]   
2. Gebreegziabher TL, Berhe DF, Gutema GB, Kabtyime BN. Drug utilization pattern and potential teratogenesity risk among pregnant women; the case of Ayder referral hospital, Tigray – Ethiopia. JPSR. 2012;3(5):1371–8.
3. Rathnakar UP, Singh N. Drug utilization patterns during antenatal period. J Pharm Res. 2011;4(10):3559–61.
4. Gawde SR, Bhide SS, PateL CC, Chauhan AR, Mayadeo NM, Sawardekar SB. Drug prescription pattern in pregnant women attending antenatal out patient department of a tertiary care hospital. Br J Pharm Res. 2013;3(1):1–12. [DOI via Crossref]   
5. Sharma R, Kapoor B, Verma B. Drug utilization pattern during pregnancy in north India. Indian J Med Sci. 2006;60(7):277–87. [DOI via Crossref]    [Pubmed]   
6. Rohra DK, Das N, Azam SI, Solangi NA, Memon Z, Shaikh AM, et al. Drug prescribing patterns during pregnancy in the tertiary care hospitals of Pakistan: a cross sectional study. BMC Pregnancy Childbirth. 2008;8:24–8. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
7. Rathore H. Diagnosis of Pregnancy and Antenatal Care 2012. Available at: http://www.academia.edu/35359/ANTENATAL_CARE [accessed May 7, 2015].
8. Adhikari A, Biswas S, Gupta RK. Drug use behaviour of pregnant women in rural India. J Pak Med Assoc. 2011;6(4):381–3.
9. Frankos VH. FDA perspectives on the use of teratology data for human risk assessment. Fundam Appl Toxicol. 1985;5(4):615–25. [DOI via Crossref]   
10. How to Investigate Drug Use in Health Facilities, Selected Drug Use Indicators, WHO/DAP/93.1. Geneva: World Health Organization 1993. Available at: http://www. apps.who.int/medicinedocs/en/d/Js2289e/. [accessed December 20, 2015].
11. Parke TB, Ford JB, Jenkins MG, Morris JM, Robert CL. Patterns and outcomes of preterm hospital admissions during pregnancy in NSW, 2001–2008. Med J Aust. 2012;196(4):261–5. [DOI via Crossref]   
12. Patel KP, Joshi HM, Patel VJ. Study of morbidity and drug utilization pattern in indoor patients of high risk pregnancy at tertiary care hospital. Int J Reprod Contracept Obstet Gynaecol. 2013;2(3):372–8. [DOI via Crossref]   
13. Kumarjit S, Manjunath GN, Dhananjaya BS, Lohit K. Prescription pattern of drugs during pregnancy in a tertiary care centre: A retrospective study. J Int Med Dentistry. 2015;2(1):30–5.
14. Huda FA, Ahmed A, Dasgupta SK, Jahan M. Profile of maternal and foetal complications during labour and delivery among women giving birth in hospitals in Matlab and Chandpur, Bangladesh. J Health Popul Nutr. 2012;30(2):131–42. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
15. Evers AC, Brouwers HA, Hukkelhoven CW, Nikkels PG, Boon J, van Egmond-Linden A, et al. Perinatal mortality and severe morbidity in low and high risk term pregnancies in the Netherlands: prospective cohort study. BMJ. 2010;341:c5639. [DOI via Crossref]    [Pubmed]   
16. Awan MM, Akbar MA, Khan MI. A study of anemia in pregnant women of railway colony, Multan. Pak J Med. 2004;43(1):112–5.
17. Bakker MK, Jentink J, Vroom F, Van Den Berg PB, De Walle HE, De Jong-Van Den Berg LT. Drug prescription pattern before during and after pregnancy for chronic, occasional and pregnancy related drugs in the Netherlands. Br J Obstet Gynecol. 2006;113:559–68. [DOI via Crossref]    [Pubmed]   
18. Tisonova J, Magulova L, Goboova M, Wawruch M, Lassanova M, Bozekova L et al. Consultation activity of two Slovak Centres for pharmacotherapy during pregnancy and lactation. Cas Lek Lesk 2006;145:154–7.
19. Wen SW, Yang T, Krewski D, Yang Q, Nimrod C, Garner P et al. Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population. J Perinatology. 2008;28: 324–9. [DOI via Crossref]    [Pubmed]   
20. Abubakar K, Abdulkadir R, Abubakar S. B, Jimoh A. O, UgwahOguejiofor J. C, Danzaki A. M. Drug utilization pattern in pregnancy in a tertiary hospital in Sokoto, North West. J Health Sci. 2014; 4(4):99–104.
21. Jimoh AO, Etuk EU, Sani Z, Hudu AS. The pattern of antibiotic use in a family medicine Department of a tertiary Hospital in Sokoto, North Western Nigeria. J Clin Diagnostic Res. 2011;5(3): 566–9.
22. Eze UI, Eferakeya AE, Oparah AC, Enato EF. Assessment of prescription profile of pregnant women visiting antenatal clinics. Pharmacy Practice. 2007;5(3):135–9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
23. Joshi H, Patel S, Patel K, Patel V. Drug use pattern during pregnancy: a prospective study at Tertiary Care Teaching Hospital. NHL J Med Sci. 2012;1(1):14–7.

How to Cite this Article
Pubmed Style

Sri Vidya BP, Nagabushan H. An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 231-235. doi:10.5455/njppp.2016.6.15012016118


Web Style

Sri Vidya BP, Nagabushan H. An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. http://www.njppp.com/?mno=215290 [Access: January 02, 2022]. doi:10.5455/njppp.2016.6.15012016118


AMA (American Medical Association) Style

Sri Vidya BP, Nagabushan H. An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 231-235. doi:10.5455/njppp.2016.6.15012016118



Vancouver/ICMJE Style

Sri Vidya BP, Nagabushan H. An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2016), [cited January 02, 2022]; 6(3): 231-235. doi:10.5455/njppp.2016.6.15012016118



Harvard Style

Sri Vidya BP, Nagabushan H (2016) An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 6 (3), 231-235. doi:10.5455/njppp.2016.6.15012016118



Turabian Style

Sri Vidya BP, Nagabushan H. 2016. An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 231-235. doi:10.5455/njppp.2016.6.15012016118



Chicago Style

Sri Vidya BP, Nagabushan H. "An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 231-235. doi:10.5455/njppp.2016.6.15012016118



MLA (The Modern Language Association) Style

Sri Vidya BP, Nagabushan H. "An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 6.3 (2016), 231-235. Print. doi:10.5455/njppp.2016.6.15012016118



APA (American Psychological Association) Style

Sri Vidya BP, Nagabushan H (2016) An observational study of pharmacological interventions in complicated pregnancies in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 231-235. doi:10.5455/njppp.2016.6.15012016118