E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
05 / 07 / 2016

 


Vitamin E improves quality of life in patients with alcoholic liver disease

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar.


Abstract
Background: Alcoholic Liver Disease (ALD) is a major cause of morbidity and mortality not only in India but also worldwide. The evidence that oxidative stress is involved in the pathogenesis of ALD and Vitamin E deficiency being well documented in patients of ALD, an antioxidant like Vitamin E could likely be beneficial in patients with ALD.

Aims and Objectives: To study the effect of Vitamin E supplementation over a period of 12 weeks on Quality of life of patients with ALD.

Materials and Methods: This is a prospective, open labeled, randomized study involving a total of 30 adult patients diagnosed with ALD who were randomized into two groups of 15 each and were designated as group A (received standard treatment) and group B (received Vitamin E along with standard treatment). Quality of life was assessed by using Chronic Liver Disease Questionnaire (CLDQ) through its various domains along with global score, as a baseline measure before and after completing the treatment period of three months in each group and the scores were recorded and compared.

Result: In group A, scores in CLDQ-FA, CLDQ-AC domains and CLDQ-Global showed a statistically highly significant (P<0.001) improvement whereas in group B, there was a statistically highly significant change in all the domains of CLDQ along with CLDQ-Global score after the treatment duration. When the differences observed in various CLDQ scores in Group A were compared with those seen in Group B, the changes in CLDQ-Global score and CLDQ-SY domain score observed in Group B were highly significant (PV0.001) and also CLDQ-AB domain and CLDQ-FA domain in Group B were statistically significant (P<0.05) compared to their respective changes observed in Group A.

Conclusion: The result of this study suggests that supplementation of Vitamin E to standard treatment has significantly improved the Quality of Life in patients with ALD as evidenced by an improvement in the CLDQ scoring.

Key words: Chronic liver disease questionnaire (CLDQ); vitamin e; alcoholic liver disease; antioxidant


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Bhanu Prakash Kolasani
Articles by Prasanand Sasidharan
Articles by Divyashanthi C M
Articles by Adithiya Kumar
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 269-275. doi:10.5455/njppp.2016.6.27012016125


Web Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. https://www.njppp.com/?mno=216599 [Access: March 14, 2024]. doi:10.5455/njppp.2016.6.27012016125


AMA (American Medical Association) Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 269-275. doi:10.5455/njppp.2016.6.27012016125



Vancouver/ICMJE Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol. (2016), [cited March 14, 2024]; 6(4): 269-275. doi:10.5455/njppp.2016.6.27012016125



Harvard Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar (2016) Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol, 6 (4), 269-275. doi:10.5455/njppp.2016.6.27012016125



Turabian Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. 2016. Vitamin E improves quality of life in patients with alcoholic liver disease. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 269-275. doi:10.5455/njppp.2016.6.27012016125



Chicago Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. "Vitamin E improves quality of life in patients with alcoholic liver disease." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 269-275. doi:10.5455/njppp.2016.6.27012016125



MLA (The Modern Language Association) Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. "Vitamin E improves quality of life in patients with alcoholic liver disease." National Journal of Physiology, Pharmacy and Pharmacology 6.4 (2016), 269-275. Print. doi:10.5455/njppp.2016.6.27012016125



APA (American Psychological Association) Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar (2016) Vitamin E improves quality of life in patients with alcoholic liver disease. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 269-275. doi:10.5455/njppp.2016.6.27012016125