E-ISSN 2231-3206 | ISSN 2320-4672
 

Review Article

Online Publishing Date:
25 / 10 / 2016

 


Cardioprotective function of progesterone: A new perspective

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar.


Abstract
Cardioprotective mechanism in females during reproductive phase is unclear. New perspective explains cardioprotective function of progesterone. Progesterone, the intermediary metabolic product in synthesis of steroid hormones, with t/2 of 30 min, stimulates respiratory center inducing respiratory alkalosis in turn lowers plasma ionic calcium. This results in decreased blood coagulability and cardiac contractility along with smooth muscle relaxation. Vascular smooth muscle relaxation, leading to generalized vasodilatation causes better tissue perfusion resulting in diminished erythropoietin, and erythrocyte count. This reduces blood viscosity and afterload on the heart. Cardiac contractility remains balanced due to opposing influences of decreased plasma ionic calcium and raised basal body temperature. On sudden withdrawal of progesterone, as during premenstrual, postpartum and postmenopausal periods, cardioprotective changes are reversed. The awareness helps to build better body buffer system, aiming to correct acid-base imbalance, during expected fluctuations of progesterone.

Key words: Respiratory Alkalosis; Muscle; Smooth; Vascular; Perimenopause; Progesterone; Vasodilation


 
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How to Cite this Article
Pubmed Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 136-142. doi:10.5455/njppp.2017.7.0927404102016


Web Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. Cardioprotective function of progesterone: A new perspective. https://www.njppp.com/?mno=242818 [Access: March 16, 2024]. doi:10.5455/njppp.2017.7.0927404102016


AMA (American Medical Association) Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 136-142. doi:10.5455/njppp.2017.7.0927404102016



Vancouver/ICMJE Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol. (2017), [cited March 16, 2024]; 7(2): 136-142. doi:10.5455/njppp.2017.7.0927404102016



Harvard Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar (2017) Cardioprotective function of progesterone: A new perspective. Natl J Physiol Pharm Pharmacol, 7 (2), 136-142. doi:10.5455/njppp.2017.7.0927404102016



Turabian Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. 2017. Cardioprotective function of progesterone: A new perspective. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 136-142. doi:10.5455/njppp.2017.7.0927404102016



Chicago Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. "Cardioprotective function of progesterone: A new perspective." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 136-142. doi:10.5455/njppp.2017.7.0927404102016



MLA (The Modern Language Association) Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar. "Cardioprotective function of progesterone: A new perspective." National Journal of Physiology, Pharmacy and Pharmacology 7.2 (2017), 136-142. Print. doi:10.5455/njppp.2017.7.0927404102016



APA (American Psychological Association) Style

Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar (2017) Cardioprotective function of progesterone: A new perspective. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 136-142. doi:10.5455/njppp.2017.7.0927404102016