Physiologic kinetic profile of glycemic response in a single dose of clonidine

Derick Erl P. Sumalapao

doi:10.5455/njppp.2017.7.0100610032017

2024, Vol: 14, Issue: 4

14 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
18 / 03 / 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(7): 701-706

doi: 10.5455/njppp.2017.7.0100610032017

Physiologic kinetic profile of glycemic response in a single dose of clonidine

Derick Erl P. Sumalapao.

Abstract
Background: Clonidine activates peripheral α-2 adrenoreceptors and influences glycemic levels.

Aim and Objective: The aim and objective of the study was to determine the physiologic kinetic profile of glycemic response in a single dose of clonidine.

Materials and Methods: Experimental data on fasting glycemic levels of Sprague-Dawley rats in a single dose intraperitoneal administration of clonidine were used to describe the rate mechanisms behind the physiologic response. Parameters of the kinetic models including zero-order, first-order, and second-order were estimated and compared using nonlinear regression analysis.

Results: Clonidine administration resulted to a dose-dependent fasting glycemic level with maximal cumulative dose effect at 4 μg/kg. The overall physiologic glycemic response behaved under zero-order and first-order kinetic models on the first 3 h, while second-order kinetic model captures the fasting glycemic levels on the 3rd-8th h after drug administration.

Conclusion: A 4 μg/kg optimal dose accentuates glycemic response behaving under a zero-order or first-order rate mechanism with maximal effect on the first 3 h after clonidine administration.

Key words: Kinetic Models; Glycemic Level; Clonidine; Zero-order; First-order; Second-order

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Derick Erl P. Sumalapao
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Derick Erl P. Sumalapao. Physiologic kinetic profile of glycemic response in a single dose of clonidine. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 701-706. doi:10.5455/njppp.2017.7.0100610032017

Web Style

Derick Erl P. Sumalapao. Physiologic kinetic profile of glycemic response in a single dose of clonidine. https://www.njppp.com/?mno=255370 [Access: March 15, 2024]. doi:10.5455/njppp.2017.7.0100610032017

AMA (American Medical Association) Style

Derick Erl P. Sumalapao. Physiologic kinetic profile of glycemic response in a single dose of clonidine. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 701-706. doi:10.5455/njppp.2017.7.0100610032017

Vancouver/ICMJE Style

Derick Erl P. Sumalapao. Physiologic kinetic profile of glycemic response in a single dose of clonidine. Natl J Physiol Pharm Pharmacol. (2017), [cited March 15, 2024]; 7(7): 701-706. doi:10.5455/njppp.2017.7.0100610032017

Harvard Style

Derick Erl P. Sumalapao (2017) Physiologic kinetic profile of glycemic response in a single dose of clonidine. Natl J Physiol Pharm Pharmacol, 7 (7), 701-706. doi:10.5455/njppp.2017.7.0100610032017

Turabian Style

Derick Erl P. Sumalapao. 2017. Physiologic kinetic profile of glycemic response in a single dose of clonidine. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 701-706. doi:10.5455/njppp.2017.7.0100610032017

Chicago Style

Derick Erl P. Sumalapao. "Physiologic kinetic profile of glycemic response in a single dose of clonidine." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 701-706. doi:10.5455/njppp.2017.7.0100610032017

MLA (The Modern Language Association) Style

Derick Erl P. Sumalapao. "Physiologic kinetic profile of glycemic response in a single dose of clonidine." National Journal of Physiology, Pharmacy and Pharmacology 7.7 (2017), 701-706. Print. doi:10.5455/njppp.2017.7.0100610032017

APA (American Psychological Association) Style

Derick Erl P. Sumalapao (2017) Physiologic kinetic profile of glycemic response in a single dose of clonidine. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 701-706. doi:10.5455/njppp.2017.7.0100610032017

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272