E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


The activity of metabolic enzymes in the saliva of lung cancer patients

Lyudmila V Belskaya, Victor K Kosenok.

Cited by (4)

Abstract
Background: So far, optimization problems for diagnostics and prognostication aids have been still relevant for lung cancer as a leader in the structure of cancers.

Aims and Objectives: A search for regularities of changes in the saliva enzyme activity in patients with lung cancer.

Materials and Methods: In the case-control study, 859 people divided into two groups took part: Primary (lung cancer, n = 286) and control (conventionally healthy, n = 573). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured by spectrophotometry. Between group differences were measured with the nonparametric test.

Results: In terms of lung cancer, we observe metabolic changes described with decreased de Ritis coefficient (P ˂ 0.001), as well as the increased activity of alanine aminotransferase (P = 0.022), alkaline phosphatase (P ˂ 0.001), gamma-glutamyl transpeptidase (P = 0.043), and α-amylase (P ˂ 0.001). We have identified specifics of the change in the enzyme activity depending on a histological type and a growth form of the tumor. There is the observable increased activity of α-amylase in the saliva in lung adenocarcinoma and neuroendocrine tumors (P ˂ 0.001). It has been found that irrespective of the histological type of lung cancer in a transition from central to peripheral forms of growth; there is the observable increased activity of all the enzymes. The significantly reduced activity of aspartate aminotransferase (by 51.4% for adenocarcinoma, P = 0.032; 48.8% for squamous cell lung cancer, P = 0.042) is a distinctive feature of central lung cancer.

Conclusion: The nature of the change in the enzyme activity is ambiguous and to a greater degree depends on the tumor form of growth (central/peripheral lung cancer) than the histological type (adenocarcinoma/squamous cell lung cancer).

Key words: Saliva; Aminotransferase; Lactate Dehydrogenase; Gamma-glutamyl Transpeptidase; Alkaline Phosphatase; α-Amylase


 
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Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives
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Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study
Diagnostics 2020; 10(12): 1095.

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A new field of application of saliva tests for prognostic purpose: focus on lung cancer
BMCRM 2020; 3(3): e00133.

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How to Cite this Article
Pubmed Style

Lyudmila V Belskaya, Victor K Kosenok. The activity of metabolic enzymes in the saliva of lung cancer patients. Natl J Physiol Pharm Pharmacol. 2017; 7(6): 646-653. doi:10.5455/njppp.2017.7.0204402032017


Web Style

Lyudmila V Belskaya, Victor K Kosenok. The activity of metabolic enzymes in the saliva of lung cancer patients. https://www.njppp.com/?mno=259550 [Access: June 01, 2022]. doi:10.5455/njppp.2017.7.0204402032017


AMA (American Medical Association) Style

Lyudmila V Belskaya, Victor K Kosenok. The activity of metabolic enzymes in the saliva of lung cancer patients. Natl J Physiol Pharm Pharmacol. 2017; 7(6): 646-653. doi:10.5455/njppp.2017.7.0204402032017



Vancouver/ICMJE Style

Lyudmila V Belskaya, Victor K Kosenok. The activity of metabolic enzymes in the saliva of lung cancer patients. Natl J Physiol Pharm Pharmacol. (2017), [cited June 01, 2022]; 7(6): 646-653. doi:10.5455/njppp.2017.7.0204402032017



Harvard Style

Lyudmila V Belskaya, Victor K Kosenok (2017) The activity of metabolic enzymes in the saliva of lung cancer patients. Natl J Physiol Pharm Pharmacol, 7 (6), 646-653. doi:10.5455/njppp.2017.7.0204402032017



Turabian Style

Lyudmila V Belskaya, Victor K Kosenok. 2017. The activity of metabolic enzymes in the saliva of lung cancer patients. National Journal of Physiology, Pharmacy and Pharmacology, 7 (6), 646-653. doi:10.5455/njppp.2017.7.0204402032017



Chicago Style

Lyudmila V Belskaya, Victor K Kosenok. "The activity of metabolic enzymes in the saliva of lung cancer patients." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 646-653. doi:10.5455/njppp.2017.7.0204402032017



MLA (The Modern Language Association) Style

Lyudmila V Belskaya, Victor K Kosenok. "The activity of metabolic enzymes in the saliva of lung cancer patients." National Journal of Physiology, Pharmacy and Pharmacology 7.6 (2017), 646-653. Print. doi:10.5455/njppp.2017.7.0204402032017



APA (American Psychological Association) Style

Lyudmila V Belskaya, Victor K Kosenok (2017) The activity of metabolic enzymes in the saliva of lung cancer patients. National Journal of Physiology, Pharmacy and Pharmacology, 7 (6), 646-653. doi:10.5455/njppp.2017.7.0204402032017