E-ISSN 2231-3206 | ISSN 2320-4672
 

Case Report

Online Publishing Date:
20 / 09 / 2017

 


Oxaliplatin-induced laryngospasm - A case report

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat.


Abstract
Oxaliplatin is third-generation platinum compound used in the treatment of colorectal cancer, gastrointestinal cancers, and few other malignancies. It is mostly used in combination regimens with 5-fluorouracil /leucovorin or capecitabine. Neurotoxicity is the major dose-limiting adverse event. Peripheral neuropathy, predominantly of sensory type occurs in 85-95% of patients. Severe immediate hypersensitivity reactions are very rare and generally occurs after the sixth cycle. Here, we report a 54-year-old female with Stage IV colon cancer who developed jaw muscle spasm, suffocation, and dysphonia during the infusion of 3rd cycle of CAPOX regimen. The reaction lasted up to 1 h even after the infusion was stopped and was managed with steroids and antihistamines. Laryngospam is a very rare side effect, so nursing staff and clinicians should be prepared for the management of such hypersensitivity reactions.

Key words: Colorectal Cancer; Malignancies; Adverse Event; Neurotoxicity; Laryngospasm; Hypersensitivity Reactions


 
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How to Cite this Article
Pubmed Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 146-148. doi:10.5455/njppp.2018.8.0726428072017


Web Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. Oxaliplatin-induced laryngospasm - A case report. https://www.njppp.com/?mno=272819 [Access: March 14, 2024]. doi:10.5455/njppp.2018.8.0726428072017


AMA (American Medical Association) Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 146-148. doi:10.5455/njppp.2018.8.0726428072017



Vancouver/ICMJE Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol. (2018), [cited March 14, 2024]; 8(1): 146-148. doi:10.5455/njppp.2018.8.0726428072017



Harvard Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat (2018) Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol, 8 (1), 146-148. doi:10.5455/njppp.2018.8.0726428072017



Turabian Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. 2018. Oxaliplatin-induced laryngospasm - A case report. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 146-148. doi:10.5455/njppp.2018.8.0726428072017



Chicago Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. "Oxaliplatin-induced laryngospasm - A case report." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 146-148. doi:10.5455/njppp.2018.8.0726428072017



MLA (The Modern Language Association) Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat. "Oxaliplatin-induced laryngospasm - A case report." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 146-148. Print. doi:10.5455/njppp.2018.8.0726428072017



APA (American Psychological Association) Style

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat (2018) Oxaliplatin-induced laryngospasm - A case report. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 146-148. doi:10.5455/njppp.2018.8.0726428072017