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Original Research

Online Publishing Date:
14 / 12 / 2017

 


Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar.


Abstract
Background: Patients with head-and-neck cancer (HNC) have various challenging symptoms due to their disease and treatment side effects which again complicate the disease progress as it has a direct implication toward their quality of life (QOL).

Aims and Objective: The aim of this study is to assess the QOL in post-operative advanced stage HNC patients on concomitant chemoradiotherapy aimed at improving locoregional control, survival, and QOL.

Materials and Methods: Thirty-two postoperative advanced HNC patients were assessed cross-sectionally for their QOL. Patients who were assessed were stable and were not in discomfort while filling the questionnaires. Assessment was done using University of Washington Version 4 QOL questionnaire, which was translated into local language (Kannada). For data analysis, patients were divided into 2 groups: Group A - patients not on chemoradiotherapy and Group B - patients on chemoradiotherapy (fluorouracil and cisplatin regimen). Mean scores were expressed as percentages.

Results: Of the thirty-two patients, ten were receiving chemotherapy with concomitant radiotherapy. Twenty-two patients did not require chemotherapy or radiation at that time. Patients in both the groups reported problems with pain, appearance, swallowing, chewing, and speech, in similar magnitudes. Patients in Group B as compared to Group A displayed reduced mean scores in the following domains - activity (24% vs. 15%), recreation (49% vs. 28%), taste (42% vs. 20%), saliva (45% vs. 30%), mood (35% vs. 17%), and anxiety (37% vs. 8%). Scoring is scaled so that a score of 0 represents the worst subjective function and a score of 100% represents no subjective deficits.

Conclusion: QOL reduces during chemoradiation largely due to psychological factors, and hence, these patients require pre- and intra-therapy counseling.

Key words: Quality of Life; Chemotherapy; Radiotherapy; Advanced Head-and-Neck Cancer


 
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Pubmed Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2018; 8(4): 517-520. doi:10.5455/njppp.2018.8.0937517112017

Web Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. https://www.njppp.com/?mno=278740 [Access: March 14, 2024]. doi:10.5455/njppp.2018.8.0937517112017

AMA (American Medical Association) Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2018; 8(4): 517-520. doi:10.5455/njppp.2018.8.0937517112017


Vancouver/ICMJE Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2018), [cited March 14, 2024]; 8(4): 517-520. doi:10.5455/njppp.2018.8.0937517112017


Harvard Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar (2018) Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. Natl J Physiol Pharm Pharmacol, 8 (4), 517-520. doi:10.5455/njppp.2018.8.0937517112017


Turabian Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. 2018. Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 8 (4), 517-520. doi:10.5455/njppp.2018.8.0937517112017


Chicago Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. "Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 517-520. doi:10.5455/njppp.2018.8.0937517112017


MLA (The Modern Language Association) Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar. "Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 8.4 (2018), 517-520. Print. doi:10.5455/njppp.2018.8.0937517112017


APA (American Psychological Association) Style

Priya Darshini Bai G, Ravi Kumar, Shashi Kumar (2018) Impact of chemotherapy with concurrent radiotherapy on quality of life in post-operative advanced head-and-neck cancer patients: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 8 (4), 517-520. doi:10.5455/njppp.2018.8.0937517112017


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