E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice

Srinivasa K, Shashi Kumara, Neetha C S.

Abstract
Background: Epilepsy is a neurological disorder distressing a large scale of the inhabitants, which accounts for about 1% of the world’s burden of diseases. A large number of groups called antiepileptic drugs are accessible to treat several types of seizures with the objective to decrease seizure incidence and ruthlessness within an outline of an acceptable level of side effects, search for an alternative antiepileptic from natural source, i.e., herbal remedies, which were used traditionally, and safe on human health, is gaining global attention.

Aims and Objectives: The objective of the study is intended to evaluate the antiepileptic activity of Saraca asoca flower (Roxb.) Wilde extract of S. asoca flower (ESAF) in Swiss albino mice.

Materials and Methods: Ethanolic ESAF was prepared by a continuous method using Soxhlet apparatus with respected temperature. EASF in the doses 50, 100 mg/kg bodyweight along with valproate was administrated to albino mice by oral route followed by antiepileptic activity was evaluated by maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizure models. Abolition of tonic hind limb extension (THLE) phase and increase in seizure latency period, when compared to control group, were taken as a measure of protection in MES- and PTZ-induced convulsion model, respectively. The results are expressed as mean ± standard error of the mean. Statistical analysis was done by one-way analysis of variance test followed by post hoc Dunnett’s multiple comparison tests. P < 0.05 was considered statistically significant.

Results: ESAF in the dose of 50 and 100 mg/kg bodyweight showed significant antiepileptic property in both MES and PTZ seizure models. There was significant abolition of THLE phase in MES model. There was also significant increase in seizure latency in PTZ-induced seizure model.

Conclusion: ESAF possesses significant antiepileptic activity. Further, investigations are required to determine its active constituents and also its mechanism of action.

Key words: Saraca asoca Flower; Maximal Electroshock; Pentylenetetrazole; Anticonvulsant; Immobility


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Srinivasa K
Articles by Shashi Kumara
Articles by Neetha C S
on Google
on Google Scholar
Article Statistics
 Viewed: 324
Downloaded: 134
Cited: 0

How to Cite this Article
Pubmed Style

K S, Kumara S, S NC. Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2018; 8(6): 858-862. doi:10.5455/njppp.2018.8.1249631012018


Web Style

K S, Kumara S, S NC. Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. http://www.njppp.com/?mno=286844 [Access: June 19, 2018]. doi:10.5455/njppp.2018.8.1249631012018


AMA (American Medical Association) Style

K S, Kumara S, S NC. Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2018; 8(6): 858-862. doi:10.5455/njppp.2018.8.1249631012018



Vancouver/ICMJE Style

K S, Kumara S, S NC. Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. Natl J Physiol Pharm Pharmacol. (2018), [cited June 19, 2018]; 8(6): 858-862. doi:10.5455/njppp.2018.8.1249631012018



Harvard Style

K, S., Kumara, S. & S, N. C. (2018) Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. Natl J Physiol Pharm Pharmacol, 8 (6), 858-862. doi:10.5455/njppp.2018.8.1249631012018



Turabian Style

K, Srinivasa, Shashi Kumara, and Neetha C S. 2018. Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (6), 858-862. doi:10.5455/njppp.2018.8.1249631012018



Chicago Style

K, Srinivasa, Shashi Kumara, and Neetha C S. "Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 858-862. doi:10.5455/njppp.2018.8.1249631012018



MLA (The Modern Language Association) Style

K, Srinivasa, Shashi Kumara, and Neetha C S. "Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 8.6 (2018), 858-862. Print. doi:10.5455/njppp.2018.8.1249631012018



APA (American Psychological Association) Style

K, S., Kumara, S. & S, N. C. (2018) Evaluation of anticonvulsant activity of Saraca asoca flower (Roxb.) Wilde in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (6), 858-862. doi:10.5455/njppp.2018.8.1249631012018





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Most Cited Articles
  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 4 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 4 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 4 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 4 times [Click to see citing articles]

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31
    Cited : 3 times [Click to see citing articles]