E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit.

Abstract
Background: Abdominal obesity is seen with increased prevalence in South Asians even among those who have a body mass index (BMI) <25 kg/m2. Increasing intra-abdominal deposition of fat is closely associated with prolongation of the QTc interval independent of obesity and other cardiovascular risk factors. This may facilitate the development of cardiac arrhythmias and sudden death.

Aims and Objectives: To determine whether abdominal obesity is associated with a prolongation of the QT interval corrected for heart rate (QTc) on the electrocardiogram (EKG) in Indian males with normal BMI.

Materials and Methods: It was a cross-sectional study involving 100 males with normal BMI (50 with abdominal obesity and 50 healthy controls). Demographic data and detailed medical history were taken from each participant. Height, weight, waist, and hip circumference were measured. Participants were divided into two groups, one with waist-hip ratio (WHR) <0.9 and other with WHR ‚Č•0.9. A resting standard supine 12-lead EKG was recorded. QTc interval was calculated using Bazettís formula (QTc = QT interval/square root R-R interval). Student t-test and Pearsonís correlation coefficient were used for statistical analysis.

Results: There was no significant difference between Groups I and II in mean age, weight, height, and BMI (P > 0.05). QTc was found to be significantly higher in Group with WHR ‚Č•0.9 with P < 0.001. In the group with WHR ‚Č•0.9, 26% subjects had abnormal QTc, and 50% had borderline prolongation. In the other group, only one participant (2%) had abnormally prolonged QTc and 90% had QTc within normal limits. Significant positive correlation of QTc was found with weight, BMI and WHR with P value of P < 0.05, while there was no significant correlation of QTc with age and height.

Conclusion: Distribution of adiposity needs to be taken into account even in normal weight and BMI patients while judging the cardiovascular and metabolic risk. WHR is a better indicator of prolonged QTc interval in these individuals than BMI.

Key words: Abdominal Obesity; QTc; Waist-hip Ratio


 
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Pubmed Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. Natl J Physiol Pharm Pharmacol. 2018; 8(7): 920-923. doi:10.5455/njppp.2018.8.0207423022018


Web Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. http://www.njppp.com/?mno=291742 [Access: November 14, 2018]. doi:10.5455/njppp.2018.8.0207423022018


AMA (American Medical Association) Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. Natl J Physiol Pharm Pharmacol. 2018; 8(7): 920-923. doi:10.5455/njppp.2018.8.0207423022018



Vancouver/ICMJE Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. Natl J Physiol Pharm Pharmacol. (2018), [cited November 14, 2018]; 8(7): 920-923. doi:10.5455/njppp.2018.8.0207423022018



Harvard Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit (2018) Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. Natl J Physiol Pharm Pharmacol, 8 (7), 920-923. doi:10.5455/njppp.2018.8.0207423022018



Turabian Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. 2018. Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. National Journal of Physiology, Pharmacy and Pharmacology, 8 (7), 920-923. doi:10.5455/njppp.2018.8.0207423022018



Chicago Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. "Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 920-923. doi:10.5455/njppp.2018.8.0207423022018



MLA (The Modern Language Association) Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit. "Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity." National Journal of Physiology, Pharmacy and Pharmacology 8.7 (2018), 920-923. Print. doi:10.5455/njppp.2018.8.0207423022018



APA (American Psychological Association) Style

Manoj Kumar Sharma, Amit A Upadhyah, Jatin V Dhanani, Dnyanesh P Pandit (2018) Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity. National Journal of Physiology, Pharmacy and Pharmacology, 8 (7), 920-923. doi:10.5455/njppp.2018.8.0207423022018





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