E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study

Harish G Bagewadi, Rajeshwari, Banderao V Patil.

Abstract
Background: Around 5–10% of patients on selective serotonin reuptake inhibitors discontinue therapy because of side effects. Therefore, research for newer antidepressants with greater effectiveness has to be explored.

Aims and Objectives: The present study is undertaken to evaluate the antidepressant activity of memantine in Swiss albino mice.

Materials and Methods: They were divided into four groups containing six mice in each group. First group mice were given normal saline (control) 10 mL/kg, fluoxetine (20 mg/kg, i.p.) as standard for the second group and for third group memantine 3 mg/kg (test drug), and memantine plus fluoxetine (3 mg/kg + 20 mg/kg) for the fourth group intraperitoneally daily for 15 consecutive days. Duration of immobility was observed for 4 min in forced swimming test. Duration of locomotor activity was observed in photoactometer. Results were analyzed by ANOVA followed by post hoc Tukey’s test.

Results: Memantine significantly reduced the immobility time in forced swim test compared to control (P < 0.001). Memantine showed no significant effect on locomotor activity in photoactometer. Memantine showed synergistic antidepressant effect with fluoxetine when combined together.

Conclusion: N-methyl-D-aspartate antagonist, memantine has showed significant antidepressant activity in experimental models of depression in mice.

Key words: Memantine; N-methyl-D-aspartate -antagonist; Forced Swim Test; Anti-depressant; Fluoxetine


 
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Pubmed Style

Bagewadi HG, , Patil BV. Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. Natl J Physiol Pharm Pharmacol. 2018; 8(7): 964-968. doi:10.5455/njppp.2018.8.0208004032018


Web Style

Bagewadi HG, , Patil BV. Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. http://www.njppp.com/?mno=292296 [Access: July 16, 2018]. doi:10.5455/njppp.2018.8.0208004032018


AMA (American Medical Association) Style

Bagewadi HG, , Patil BV. Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. Natl J Physiol Pharm Pharmacol. 2018; 8(7): 964-968. doi:10.5455/njppp.2018.8.0208004032018



Vancouver/ICMJE Style

Bagewadi HG, , Patil BV. Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. Natl J Physiol Pharm Pharmacol. (2018), [cited July 16, 2018]; 8(7): 964-968. doi:10.5455/njppp.2018.8.0208004032018



Harvard Style

Bagewadi, H. G., & Patil, B. V. (2018) Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. Natl J Physiol Pharm Pharmacol, 8 (7), 964-968. doi:10.5455/njppp.2018.8.0208004032018



Turabian Style

Bagewadi, Harish G, Rajeshwari, and Banderao V Patil. 2018. Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 8 (7), 964-968. doi:10.5455/njppp.2018.8.0208004032018



Chicago Style

Bagewadi, Harish G, Rajeshwari, and Banderao V Patil. "Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 964-968. doi:10.5455/njppp.2018.8.0208004032018



MLA (The Modern Language Association) Style

Bagewadi, Harish G, Rajeshwari, and Banderao V Patil. "Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study." National Journal of Physiology, Pharmacy and Pharmacology 8.7 (2018), 964-968. Print. doi:10.5455/njppp.2018.8.0208004032018



APA (American Psychological Association) Style

Bagewadi, H. G., & Patil, B. V. (2018) Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 8 (7), 964-968. doi:10.5455/njppp.2018.8.0208004032018





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