E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A study of serum nitric oxide levels and pulse pressure in aging

Rathna Kumari Udayakumar, Anitha Muthupandian.

Abstract
Background: Nitric oxide (NO) is one of the major signaling messengers in the cardiovascular system. A sufficient level of endothelial NO is necessary to preserve normal vascular physiology and is one of the regulators of pulse pressure. Aging is linked to a gradual decrease of NO activity in the vessel wall. Hence, we tried to find a relationship between serum NO levels and pulse pressure in aging.

Aims and Objective: The aim and objective of this study are to estimate serum NO levels and pulse pressure in normal aging.

Materials and Methods: A total of 90 healthy male subjects aged between 70 and 80 otals were randomly selected. Fasting blood samples of the subjects were obtained for the estimation of serum NO levels (Griess method). NO concentration is indirectly measured by means of accurately quantifying the levels of nitrite (NO2-). The resting pulse pressure of the subjects was recorded on 3 consecutive days, and the average of the three values was recorded.

Results: The mean pulse pressure of the study population was 60.6 ± 6.2 mm Hg, and the mean serum NO level was 27.9 ± 9.9 (μM). A negative correlation was observed between serum NO levels and pulse pressure. The Pearson’s coefficient of correlation was r = −0.398 which is statistically significant at the 0.05 level (one-tailed).

Conclusion: In our study population of 90 urban dwelling elderly men (mean age 74 ± 3 years), we observed that higher levels of serum NO levels were associated with lower pulse pressures.

Key words: Nitric Oxide; Pulse Pressure; Nitrite (NO2-); Griess Method


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Rathna Kumari Udayakumar
Articles by Anitha Muthupandian
on Google
on Google Scholar
Article Statistics
 Viewed: 567
Downloaded: 277
Cited: 0

How to Cite this Article
Pubmed Style

Rathna Kumari Udayakumar, Anitha Muthupandian. A study of serum nitric oxide levels and pulse pressure in aging. Natl J Physiol Pharm Pharmacol. 2018; 8(9): 1262-1264. doi:10.5455/njppp.2018.8.0416903052018


Web Style

Rathna Kumari Udayakumar, Anitha Muthupandian. A study of serum nitric oxide levels and pulse pressure in aging. http://www.njppp.com/?mno=297904 [Access: November 16, 2018]. doi:10.5455/njppp.2018.8.0416903052018


AMA (American Medical Association) Style

Rathna Kumari Udayakumar, Anitha Muthupandian. A study of serum nitric oxide levels and pulse pressure in aging. Natl J Physiol Pharm Pharmacol. 2018; 8(9): 1262-1264. doi:10.5455/njppp.2018.8.0416903052018



Vancouver/ICMJE Style

Rathna Kumari Udayakumar, Anitha Muthupandian. A study of serum nitric oxide levels and pulse pressure in aging. Natl J Physiol Pharm Pharmacol. (2018), [cited November 16, 2018]; 8(9): 1262-1264. doi:10.5455/njppp.2018.8.0416903052018



Harvard Style

Rathna Kumari Udayakumar, Anitha Muthupandian (2018) A study of serum nitric oxide levels and pulse pressure in aging. Natl J Physiol Pharm Pharmacol, 8 (9), 1262-1264. doi:10.5455/njppp.2018.8.0416903052018



Turabian Style

Rathna Kumari Udayakumar, Anitha Muthupandian. 2018. A study of serum nitric oxide levels and pulse pressure in aging. National Journal of Physiology, Pharmacy and Pharmacology, 8 (9), 1262-1264. doi:10.5455/njppp.2018.8.0416903052018



Chicago Style

Rathna Kumari Udayakumar, Anitha Muthupandian. "A study of serum nitric oxide levels and pulse pressure in aging." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1262-1264. doi:10.5455/njppp.2018.8.0416903052018



MLA (The Modern Language Association) Style

Rathna Kumari Udayakumar, Anitha Muthupandian. "A study of serum nitric oxide levels and pulse pressure in aging." National Journal of Physiology, Pharmacy and Pharmacology 8.9 (2018), 1262-1264. Print. doi:10.5455/njppp.2018.8.0416903052018



APA (American Psychological Association) Style

Rathna Kumari Udayakumar, Anitha Muthupandian (2018) A study of serum nitric oxide levels and pulse pressure in aging. National Journal of Physiology, Pharmacy and Pharmacology, 8 (9), 1262-1264. doi:10.5455/njppp.2018.8.0416903052018





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Most Cited Articles
  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 5 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138
    Cited : 4 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 4 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 4 times [Click to see citing articles]