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Original Research 


Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A.

Cited by (1)

Abstract
Background: Increasing the use of traditional therapy is an obvious reality in some country. The bark of Khaya senegalensis is suspected to treat diabetes. That is what this type of work is started.

Aims & Objective: The aim of this work is to test the effect of total Khaya senegalensis barks extracts on the hepatic liberation of glucose in vitro.

Materials and Methods: The dried extracts obtained from barks powder had been prepared at concentrations of 0, 2, 5, 10 and 20 ÎĽg/L and applied on fragments of mice Wistar isolated liver, kept in Mack -Ewen solution. After incubation at 37°C in oven, glucose level in the solution had been measured by spectrophometer, using GOD-PAP® regent, for each extracts concentration at the times T=0, 10, 20, 30, 40, 50 and 60 minutes.

Results: Glucose level in the solution had varied in time function from one extracts concentration to another. Khaya senegalensis barks total extracts had reduced hepatic liberation of glucose. This effect had been comparable to the effect of insulin 2,5IU solution used like reference substance in this experimentation. The total extracts of Khaya senegalensis barks could actuate on enzymes implicated in the metabolism of intra hepatocytary glucose.

Conclusion: This investigation had been coupled to phytochimic analyses that showed the presence of saponoďdes, anthracitic derivers and steroids in Khaya senegalensis barks.

Key words: Insulin; Glucose; Liver Fragments; Khaya Senegalensis; Hepatic Liberation Of Glucose; Mice Wistar


 
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REFERENCES
1.Adjotin P. Médecinestraditionnellesetmédecinemoderne au Bénin. Collaborations ouconflits ? (Mémoire de DES) Genève :Institutuniversitaired'études du développement (IUED), 1996. p. 57.
2.Lehninger AL, Nelson DL. Principios de Bioquimica. 2da Edicion. Spain : Omega 1999. p. 453-6.
3.Grimaldi A, Jacqueminet S, Heurtier A, Bosquet F, Collectif. Guide pratique du diabète. 3e édition. Médiguides (Paris): Elsevier Masson. 2005. p. 271.
4.Juss A. CTFT Khayasemgalensis (Desr.). Bois et Forêts des Tropiques, no 218, 4è trimestre; 1988 : 43-55.
5.Christine O. Contribution Ă  la conservation du Khayasenegalensis (Desr). A.JUSS: importance socio-Ă©conomique, structure etdynamiques des peuplementsnaturels et productivitĂ©s des plantations d’essai au BĂ©nin. 2000.
6.Koukoui ASI. Omédine. étude des signauxcalciqueshépatocytairesinduits par différentsagonistesmodulateurs de la sécrétionbiliaire et de la production hépatique du glucose : acidesbiliaires, prostaglandines et glucagon. Thèse de doctorat en signalisationcellulaire, endocrinologie, reproduction/science de la vie.2005. p. 169.
7.Boullard B. Dictionnaireplantesmédicinales du monde. Réalitéetcroyance. Ed ESTEM 7, paris: De BoeckSecundair, 2001. p. 636.
8.Yaro B. Contribution Ă  l’Ă©tude du traitementtraditionnel du diabète au mali. thèse de pharmacie. 1992. p. 133.
9.Coulibaly B. Contribution Ă  l’Ă©tude des remèdestraditionnelsutilisĂ©sdans le traitement du diabète au mali. Thèse de pharmacie. 1988. p.113.
10.Gbenou JD, Oyeniran C. Contribution Ă  l’Ă©tude des propriĂ©tĂ©shypoglycĂ©miantes de l’huileessentielled’Eucalyptuscanaldulensis. MĂ©moire de MaĂ®trise en physiologie. Cotonou;BĂ©nin 2004;33-45.
11.Keita A, Mariko E. Etude de l’activitĂ©hypoglycĂ©miante des feuilles de Scleraryabirrea, revue MĂ©decineTraditionnelleAfricaine 1998; 10 :16-25
12.Lawson-evi P, Eklu-Gadegbeku. Activitéhypoglycémiante de quelquesplantesmédicinales. Revue MédecinetraditionnelleAfricaine 1997;1(9):60-69.
13.Oga ASS, Tebi A, Aka J, AdouĂ©ni KV, Malan KA, Kouadio LP, Lokrou. Le diabètesucrĂ©diagnostiquĂ© en CĂ´te d’Ivoire: des particularitĂ©sĂ©pidĂ©miologiques. Med 2006;66:241-6.
14.Rao BK, Rao CH. Hypoglycemic and antihyperglycemic activity of, syzygiumalternifolium (wt) Walp. Seed extracts in normal and diabetic rat. Phytomedecine 2001;8:88-93. [DOI via Crossref]   
15.Goodman, G. Gilman, G. Bases Farmacológicas de la Terapéutica. 7th Edición. México: McGraw- Hill. 1994. p. 1459-70.
16.World Health Organization. Rapport de l’OMS. Press Release WHO/38. 16 May 2002.

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How to Cite this Article
Pubmed Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. Natl J Physiol Pharm Pharmacol. 2014; 4(2): 112-117. doi:10.5455/njppp.2014.4.290920133


Web Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. http://www.njppp.com/?mno=43231 [Access: January 01, 2022]. doi:10.5455/njppp.2014.4.290920133


AMA (American Medical Association) Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. Natl J Physiol Pharm Pharmacol. 2014; 4(2): 112-117. doi:10.5455/njppp.2014.4.290920133



Vancouver/ICMJE Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. Natl J Physiol Pharm Pharmacol. (2014), [cited January 01, 2022]; 4(2): 112-117. doi:10.5455/njppp.2014.4.290920133



Harvard Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A (2014) Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. Natl J Physiol Pharm Pharmacol, 4 (2), 112-117. doi:10.5455/njppp.2014.4.290920133



Turabian Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. 2014. Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. National Journal of Physiology, Pharmacy and Pharmacology, 4 (2), 112-117. doi:10.5455/njppp.2014.4.290920133



Chicago Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. "Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose." National Journal of Physiology, Pharmacy and Pharmacology 4 (2014), 112-117. doi:10.5455/njppp.2014.4.290920133



MLA (The Modern Language Association) Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A. "Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose." National Journal of Physiology, Pharmacy and Pharmacology 4.2 (2014), 112-117. Print. doi:10.5455/njppp.2014.4.290920133



APA (American Psychological Association) Style

Takin M, Ahokpe M, Zohoun L, Assou E, Aivodji N, Agossou E, Sezan A (2014) Effect of total Khaya senegalensis (Meliaceae) barks extracts on hepatic liberation of glucose. National Journal of Physiology, Pharmacy and Pharmacology, 4 (2), 112-117. doi:10.5455/njppp.2014.4.290920133