E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Platelet aggregation and clotting time in type 2 diabetic males

Sunita Dhule, Swati Gawali.

Cited by (3)

Abstract
Background: Diabetes mellitus is a heterogeneous disorder that affects cellular metabolism in variety of ways and coagulation indices are reported to be adversely affected.Insulin resistance is a marked pathophysiology of Type II diabetes causing abnormalities in the microvascular and macrovascular circulations. The entire coagulation cascade is dysfunctional in such condition. Platelets may assume an important role in atherosclerosis in diabetes. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are haematological indices that give an idea about the coagulation status of patients. Hence the present study is undertaken to see the effect of diabetes on platelet aggregation and coagulation parameters like PT and APTT.

Aims & Objective: To study platelet aggregation and clotting time (PT, APTT) in type II diabetic males.

Materials and Methods: The present study included 30 type II diabetic males and 30 normal male subjects. Platelet aggregation was studied by O Brein J R method using ADP reagent. Clotting time (prothrombin time, activated partial thromboplastin time) was estimated by using coagulometer.

Results: ADP induced platelet aggregation was significantly higher while PT and APTT were significantly lower in diabetic group compared with control group (p<0.05) by applying unpaired ‘t’ test.

Conclusion: Our study showed increased platelet agreeability and decreased PT, APTT in type II diabetic males. So, type II diabetic patients are more prone to diseases such as coronary artery disease, cerebrovascular disease and peripheral vascular disease.
Key Words

Key words: Diabetes Mellitus; Platelet Aggregation; Prothrombin Time (PT); Activated Partial Thromboplastin Time (APTT); Insulin


 
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How to Cite this Article
Pubmed Style

Sunita Dhule, Swati Gawali. Platelet aggregation and clotting time in type 2 diabetic males. Natl J Physiol Pharm Pharmacol. 2014; 4(2): 121-123. doi:10.5455/njppp.2014.4.290920131


Web Style

Sunita Dhule, Swati Gawali. Platelet aggregation and clotting time in type 2 diabetic males. https://www.njppp.com/?mno=43537 [Access: June 01, 2022]. doi:10.5455/njppp.2014.4.290920131


AMA (American Medical Association) Style

Sunita Dhule, Swati Gawali. Platelet aggregation and clotting time in type 2 diabetic males. Natl J Physiol Pharm Pharmacol. 2014; 4(2): 121-123. doi:10.5455/njppp.2014.4.290920131



Vancouver/ICMJE Style

Sunita Dhule, Swati Gawali. Platelet aggregation and clotting time in type 2 diabetic males. Natl J Physiol Pharm Pharmacol. (2014), [cited June 01, 2022]; 4(2): 121-123. doi:10.5455/njppp.2014.4.290920131



Harvard Style

Sunita Dhule, Swati Gawali (2014) Platelet aggregation and clotting time in type 2 diabetic males. Natl J Physiol Pharm Pharmacol, 4 (2), 121-123. doi:10.5455/njppp.2014.4.290920131



Turabian Style

Sunita Dhule, Swati Gawali. 2014. Platelet aggregation and clotting time in type 2 diabetic males. National Journal of Physiology, Pharmacy and Pharmacology, 4 (2), 121-123. doi:10.5455/njppp.2014.4.290920131



Chicago Style

Sunita Dhule, Swati Gawali. "Platelet aggregation and clotting time in type 2 diabetic males." National Journal of Physiology, Pharmacy and Pharmacology 4 (2014), 121-123. doi:10.5455/njppp.2014.4.290920131



MLA (The Modern Language Association) Style

Sunita Dhule, Swati Gawali. "Platelet aggregation and clotting time in type 2 diabetic males." National Journal of Physiology, Pharmacy and Pharmacology 4.2 (2014), 121-123. Print. doi:10.5455/njppp.2014.4.290920131



APA (American Psychological Association) Style

Sunita Dhule, Swati Gawali (2014) Platelet aggregation and clotting time in type 2 diabetic males. National Journal of Physiology, Pharmacy and Pharmacology, 4 (2), 121-123. doi:10.5455/njppp.2014.4.290920131