E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
29 / 05 / 2019

 


A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure

Parul Sharma, Maloy B Mandal .


Abstract
Background: Prevailing standard of living allows generous usage of plastic containers to store, transport, and serve edibles. A chemical named bisphenol A (BPA) leaches from plastic containers into the edibles. Ingestion of BPA contaminated food is known to alter intestinal motility in addition to detrimental effects on fetal development, fertility, behavior, cognitive functions, immunity, and metabolism. These BPA-induced ill effects on health led to marketing regulation on BPA and introduction of bisphenol S (BPS) as a safer substitute of BPA. However, BPS is yet to be evaluated for its effects on gut motility.

Aims and Objectives: Therefore, this study was aimed to assess comparative effects of BPS and BPA on gut motility.

Materials and Methods: In an organ bath preparation, isometric contractions were recorded from segments of dissected gastric and small intestinal muscle strips prepared from rat gut, and cumulative concentration response of BPS and BPA on in vitro gut contractility was evaluated.

Results: Both BPS and BPA treatment significantly diminished basal tone, maximum contractile tension, and the contractile frequency of spontaneous contractions in gastric as well as small intestinal muscle strips.

Conclusion: From the present observation, it was apparent that both BPA and BPS have similar toxicity on gastric as well as small intestinal motility. Thus, the use of BPS as a substitute of BPA needs to be more critically evaluated.

Key words: Bisphenol A; Bisphenol S; Gut Motility; Plastic Toxins; In vitro Gut Contractility; Gastric Contractility; Small Intestinal Contractility; Albino Rats


 
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How to Cite this Article
Pubmed Style

Sharma P, MBM, . A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 661-667. doi:10.5455/njppp.2019.9.0414916052019


Web Style

Sharma P, MBM, . A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. https://www.njppp.com/?mno=43809 [Access: March 14, 2024]. doi:10.5455/njppp.2019.9.0414916052019


AMA (American Medical Association) Style

Sharma P, MBM, . A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 661-667. doi:10.5455/njppp.2019.9.0414916052019



Vancouver/ICMJE Style

Sharma P, MBM, . A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol. (2019), [cited March 14, 2024]; 9(7): 661-667. doi:10.5455/njppp.2019.9.0414916052019



Harvard Style

Sharma, P., , M. B. M. . & (2019) A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol, 9 (7), 661-667. doi:10.5455/njppp.2019.9.0414916052019



Turabian Style

Sharma, Parul, Maloy B Mandal, and . 2019. A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 661-667. doi:10.5455/njppp.2019.9.0414916052019



Chicago Style

Sharma, Parul, Maloy B Mandal, and . "A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 661-667. doi:10.5455/njppp.2019.9.0414916052019



MLA (The Modern Language Association) Style

Sharma, Parul, Maloy B Mandal, and . "A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure." National Journal of Physiology, Pharmacy and Pharmacology 9.7 (2019), 661-667. Print. doi:10.5455/njppp.2019.9.0414916052019



APA (American Psychological Association) Style

Sharma, P., , M. B. M. . & (2019) A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 661-667. doi:10.5455/njppp.2019.9.0414916052019