Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies

Mariette Sindete; Adam Gbankoto; Habib Ganfon; Razack Osseni; Achille Yemoa; Anatole Laleye

doi:10.5455/njppp.2019.9.1034131102019

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Online Publishing Date:
15 / 11 / 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1267-1277

doi: 10.5455/njppp.2019.9.1034131102019

Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies

Mariette Sindete, Adam Gbankoto, Habib Ganfon, Razack Osseni, Achille Yemoa, Anatole Laleye.

Abstract
Background: Caesalpinia bonduc (CB) root is used in African Pharmacopoeia for the prevention and treatment of sexual failure.

Aims and Objective: The current study performed to evaluate the acute and subacute oral toxicity of the ethanolic extract of CB root.

Materials and Methods: Two groups of three female Wistar rats were used for acute oral toxicity test. A single dose of 2000 mg/kg body weight (BW) of the ethanolic extract of CB root was administered to the test group; the control group received dimethyl sulfoxide. Rats were observed individually during the first 4 h and then daily until days 14. For subacute toxicity model, the male rats were divided into four groups (n = 6). Experimental groups received 31, 25, 125, and 500 mg/kg of BW of the ethanolic extract of CB root orally daily for 28 days. The blood hematological and biochemical parameters, as well as histopathology of liver and kidneys, were studies.

Results: No toxicological signs were observed in rats when acutely exposed to the ethanolic extract of CB root. After the repeated administration of CB root extract, hematological and biochemical parameters were unaltered except hemoglobin and erythrocyte number in the exposed animal, but they were considered to be temporary effects and not an indication of toxic effects. No macroscopic changes and no noticeable histological changes were seen in the histopathology analysis of kidneys and liver.

Conclusion: Ethanolic extract of CB root at single dosage level up to 2000 mg/Kg BW is nontoxic and can show protection of some vital organs when administered to 28 days.

Key words: Caesalpinia bonduc; Wistar Rat; Acute Toxicity; Subacute Toxicity; Histopathology

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How to Cite this Article

Pubmed Style

Sindete M, Gbankoto A, Ganfon H, Osseni R, Yemoa A, Laleye A. Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

Web Style

Sindete M, Gbankoto A, Ganfon H, Osseni R, Yemoa A, Laleye A. Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. https://www.njppp.com/?mno=68491 [Access: March 15, 2024]. doi:10.5455/njppp.2019.9.1034131102019

AMA (American Medical Association) Style

Sindete M, Gbankoto A, Ganfon H, Osseni R, Yemoa A, Laleye A. Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

Vancouver/ICMJE Style

Sindete M, Gbankoto A, Ganfon H, Osseni R, Yemoa A, Laleye A. Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. Natl J Physiol Pharm Pharmacol. (2019), [cited March 15, 2024]; 9(12): 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

Harvard Style

Sindete, M., Gbankoto, . A., Ganfon, . H., Osseni, . R., Yemoa, . A. & Laleye, . A. (2019) Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. Natl J Physiol Pharm Pharmacol, 9 (12), 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

Turabian Style

Sindete, Mariette, Adam Gbankoto, Habib Ganfon, Razack Osseni, Achille Yemoa, and Anatole Laleye. 2019. Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

Chicago Style

Sindete, Mariette, Adam Gbankoto, Habib Ganfon, Razack Osseni, Achille Yemoa, and Anatole Laleye. "Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

MLA (The Modern Language Association) Style

Sindete, Mariette, Adam Gbankoto, Habib Ganfon, Razack Osseni, Achille Yemoa, and Anatole Laleye. "Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies." National Journal of Physiology, Pharmacy and Pharmacology 9.12 (2019), 1267-1277. Print. doi:10.5455/njppp.2019.9.1034131102019

APA (American Psychological Association) Style

Sindete, M., Gbankoto, . A., Ganfon, . H., Osseni, . R., Yemoa, . A. & Laleye, . A. (2019) Safety assessment of the ethanol extract of Caesalpinia bonduc (L.) Roxb. Root in Wistar rats: Acute and subacute (28-day) oral toxicity studies. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1267-1277. doi:10.5455/njppp.2019.9.1034131102019

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